A Critical Reassessment of the Role of Mitochondria in Tumorigenesis 英文参考文献.docVIP

o Openaccess,freelyavailableonline PL S MEDICINE ACriticalReassessmentoftheRole ofMitochondriainTumorigenesis Antonio Salas1,2*,Yong-Gang Yao3,Vincent Macaulay4,Ana Vega2,5,Angel′ Carracedo1,2,5,Hans-Ju¨rgen Bandelt6 1 Unidade de Xene′tica, Instituto de Medicina Legal, Facultade de Medicina, Universidad de Santiago de Compostela, Galicia, Spain, 2 Centro Nacional de Genotipado (CeGen),HospitalCl?′nicoUniversitario,SantiagodeCompostela,Galicia,Spain,3KeyLaboratoryofCellularandMolecularEvolution,KunmingInstituteofZoology,Chinese Academy of Sciences, Kunming, Yunnan, China, 4 Department of Statistics, University of Glasgow, Glasgow, Scotland, United Kingdom, 5 Fundacio′n Pu′blica Galega de MedicinaXeno′mica(FPGMX),HospitalCl?′nicoUniversitario,UniversidaddeSantiagodeCompostela,Galicia,Spain,6DepartmentofMathematics,UniversityofHamburg, Hamburg,Germany CompetingInterests:Theauthors havedeclaredthatnocompeting interestsexist. ABSTRACT Background AuthorContributions:AS,YGY,VM, AV,AC,andHJBdesignedthestudy, analyzedthedata,andcontributed towritingthepaper. Mitochondrial DNA (mtDNA) is being analyzed by an increasing number of laboratories in ordertoinvestigateitspotentialroleasanactivemarkeroftumorigenesisinvarioustypesof cancer. Here we question the conclusions drawn in most of these investigations, especially those published in high-rank cancer research journals, under the evidence that a significant numberofthesemedicalmtDNAstudiesarebasedonobviouslyflawedsequencingresults. AcademicEditor:DougTurnbull, UniversityofNewcastleuponTyne, UnitedKingdom Citation:SalasA,YaoYG,Macaulay V,VegaA,CarracedoA′,etal.(2005) Acriticalreassessmentoftheroleof mitochondriaintumorigenesis.PLoS Med2(11):e296. MethodsandFindings Inouranalyses,wetakeaphylogeneticapproachandemploythoroughdatabasesearches, which together have proven successful for detecting erroneous sequences in the fields of human population genetics and forensics. Apart from conceptual problems concerning the inter