A Genome Wide Association Scan of Bovine Tuberculosis Susceptibility in Holstein-Friesian Dairy Cattle 英文参考文献.docVIP

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A Genome Wide Association Scan of Bovine Tuberculosis Susceptibility in Holstein-Friesian Dairy Cattle 英文参考文献.doc

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A Genome Wide Association Scan of Bovine Tuberculosis Susceptibility in Holstein-Friesian Dairy Cattle 英文参考文献

AGenomeWideAssociationScanofBovineTuberculosis SusceptibilityinHolstein-FriesianDairyCattle EmmaK.Finlay1,DonaghP.Berry2,BrianWickham3,EamonnP.Gormley4,DanielG.Bradley1* 1DepartmentofGenetics,SmurfitInstitute,TrinityCollegeDublin,Dublin,Ireland,2AnimalandGrasslandResearchandInnovationCentre,Teagasc,Moorepark,Fermoy, CountyCork,Ireland,3IrishCattleBreedingFederation,ShinaghHouse,Bandon,CountyCork,Ireland,4SchoolofAgriculture,FoodScienceandVeterinaryMedicine, VeterinarySciencesCentre,UniversityCollegeDublin,Belfield,Dublin,Ireland Abstract Background: Bovine tuberculosis is a significant veterinary and financial problem in many parts of the world. Although manyfactorsinfluenceinfectionandprogressionofthedisease,thereisahostgeneticcomponentanddissectionofthis mayenlightenonthewiderbiologyofhostresponsetotuberculosis.However,abinaryphenotypeofpresence/absenceof infectionpresentsanoisysignalforgenomewideassociationstudy. Methodology/Principal Findings: We calculated a composite phenotype of genetic merit for TB susceptibility based on diseaseincidenceindaughtersofelitesiresusedforartificialinseminationintheIrishdairyherd.Thisrobustmeasurewas comparedwith44,426SNPgenotypesinthemostinformative307subjectsinagenomewideassociationanalysis.Three SNPsina65kbgenomicregiononBTA22wereassociated(i.e.p,1025,peakingatpositiop=4.0261026 )with tuberculosissusceptibility. Conclusions/Significance: A genomic region on BTA 22 was suggestively associated with tuberculosis susceptibility; it contains the taurine transporter gene SLC6A6, or TauT, which is known to function in the immune system but has not previouslybeeninvestigatedforitsroleintuberculosisinfection. Citation:FinlayEK,BerryDP,WickhamB,GormleyEP,BradleyDG(2012)AGenomeWideAssociationScanofBovineTuberculosisSusceptibilityinHolstein- FriesianDairyCattle.PLoSONE7(2):e30545.doi:10.1371/journal.pone.0030545 Editor:JeanLouisHerrmann,HopitalRaymondPoincare-UniversiteVersaillesSt.Quentin,France ReceivedJune28,2011;AcceptedDe