A Mouse to Human Search for Plasma Proteome Changes Associated with Pancreatic Tumor Development 英文参考文献.docVIP

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A Mouse to Human Search for Plasma Proteome Changes Associated with Pancreatic Tumor Development 英文参考文献.doc

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A Mouse to Human Search for Plasma Proteome Changes Associated with Pancreatic Tumor Development 英文参考文献

o PL SMEDICINE AMousetoHumanSearchforPlasmaProteome ChangesAssociatedwithPancreatic TumorDevelopment Vitor M.Faca1,Kenneth S.Song1,Hong Wang1,Qing Zhang1,Alexei L.Krasnoselsky1,Lisa F.Newcomb1, Ruben R.Plentz2,Sushma Gurumurthy2,Mark S.Redston3,Sharon J.Pitteri1,Sandra R.Pereira-Faca1,Renee C.Ireton1, Hiroyuki Katayama1,Veronika Glukhova1,Douglas Phanstiel1,Dean E.Brenner4,Michelle A.Anderson4,David Misek4, Nathalie Scholler1,Nicole D.Urban1,Matt J.Barnett1,Cim Edelstein1,Gary E.Goodman1,Mark D.Thornquist1, Martin W. McIntosh1,Ronald A.DePinho5,6,Nabeel Bardeesy2,Samir M. Hanash1* 1 Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, 2 Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, 3 Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, 4 University of Michigan,ComprehensiveCancerCenter,AnnArbor,Michigan,UnitedStatesofAmerica,5CenterforAppliedCancerScienceoftheBelferInstituteforInnovativeCancer Science, Harvard Medical School, Boston, Massachusetts, United States of America, 6 Departments of Medical Oncology, Medicine and Genetics, Dana Farber Cancer Institute,HarvardMedicalSchool,Boston,Massachusetts,UnitedStatesofAmerica Funding: See section at end of manuscript. ABSTRACT Competing Interests: See section at end of manuscript. Background Academic Editor: Steven Narod, Centre for Research in Women’s Health, Canada The complexity and heterogeneity of the human plasma proteome have presented significant challenges in the identification of protein changes associated with tumor development. Refined genetically engineered mouse (GEM) models of human cancer have beenshowntofaithfullyrecapitulatethemolecular,biological,andclinicalfeaturesofhuman disease.Here,wesoughttoexploitthemeritsofawell-characterizedGEMmodelofpancreatic cancertodeterminewhetherproteomicstechnologiesallowidentificationofproteinchanges associate