A Multi-Compartment Model for Interneurons in the Dorsal Lateral Geniculate Nucleus 英文参考文献.docVIP

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A Multi-Compartment Model for Interneurons in the Dorsal Lateral Geniculate Nucleus 英文参考文献.doc

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A Multi-Compartment Model for Interneurons in the Dorsal Lateral Geniculate Nucleus 英文参考文献

AMulti-CompartmentModelforInterneuronsinthe DorsalLateralGeniculateNucleus GeirHalnes1*,SigitaAugustinaite2,PaulHeggelund2,GauteT.Einevoll1,MicheleMigliore3 1IMT, Norwegian University of Life Sciences, As,? Norway, 2Department of Physiology, University of Oslo, Oslo, Norway, 3Institute of Biophysics, National Research Council,Palermo,Italy Abstract GABAergic interneurons (INs) in the dorsal lateral geniculate nucleus (dLGN) shape the information flow from retina to cortex, presumably by controlling the number of visually evoked spikes in geniculate thalamocortical (TC) neurons, and refiningtheirreceptivefield.TheINsexhibitarichvarietyoffiringpatterns:Depolarizingcurrentinjectionstothesomamay induce tonic firing, periodic bursting or an initial burst followed by tonic spiking, sometimes with prominent spike-time adaptation.Whenreleasedfromhyperpolarization,someINselicitreboundbursts,whileothersreturnmorepassivelytothe resting potential. A full mechanistic understanding that explains the function of the dLGN on the basis of neuronal morphology,physiologyandcircuitryiscurrentlylacking.Onewaytoapproachsuchanunderstandingisbydevelopinga detailedmathematicalmodeloftheinvolvedcellsandtheirinteractions.LimitationsofthepreviousmodelsfortheINsof thedLGNregionpreventanaccuraterepresentationoftheconceptualframeworkneededtounderstandthecomputational propertiesofthisregion.WeherepresentadetailedcompartmentalmodelofINsusing,forthefirsttime,amorphological reconstructionandasetofactivedendriticconductancesconstrainedbyexperimentalsomaticrecordingsfromINsunder severaldifferentcurrent-clampconditions.Themodelmakesanumberofexperimentallytestablepredictionsabouttherole of specific mechanisms for the firing properties observed in these neurons. In addition to accounting for the significant featuresofallexperimentaltraces,itquantitativelyreproducestheexperimentalrecordingsoftheaction-potential-firing frequencyasafunctionofinjectedcurrent.Weshowhowandwhyrelativedifferencesinconductancev