A Network-Based Approach to Visualize Prevalence and Progression of Metabolic Syndrome Components 英文参考文献.docVIP

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A Network-Based Approach to Visualize Prevalence and Progression of Metabolic Syndrome Components 英文参考文献.doc

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A Network-Based Approach to Visualize Prevalence and Progression of Metabolic Syndrome Components 英文参考文献

ANetwork-BasedApproachtoVisualizePrevalenceand ProgressionofMetabolicSyndromeComponents RobinHaring1*.,MartinRosvall2.,UweVo¨lker3,HenryVo¨lzke4,HeyoKroemer5,MatthiasNauck1, HenriWallaschofski1 1InstituteofClinicalChemistryandLaboratoryMedicine,UniversityMedicineGreifswald,Greifswald,Germany,2DepartmentofPhysics,Umea?University,Umea?,Sweden, 3Department of Functional Genomics, University Medicine Greifswald, Greifswald, Germany, 4Institute for Community Medicine, University Medicine Greifswald, Greifswald,Germany,5InstituteofPharmacology,UniversityMedicineGreifswald,Greifswald,Germany Abstract Background:Theadditionalclinicalvalueofclusteringcardiovascularriskfactorstodefinethemetabolicsyndrome(MetS) is still under debate. However, it is unclear which cardiovascular risk factors tend to cluster predominately and how individualriskfactorstateschangeovertime. MethodsResults:Weuseddatafrom3,187individualsaged20–79yearsfromthepopulation-basedStudyofHealthin Pomerania for a network-based approach to visualize clustered MetS risk factor states and their change over a five-year follow-up period. MetS was defined by harmonized Adult Treatment Panel III criteria, and each individual’s risk factor burdenwasclassifiedaccordingtothefiveMetScomponentsatbaselineandfollow-up.Weusedthemapgeneratorto depict32(25)differentstatesandhighlightthemostimportanttransitionsbetweenthe1,024(322)possiblestatesinthe weighteddirectednetwork.Atbaseline,wefoundthelargestfraction(19.3%)ofallindividualsfreeofanyMetSriskfactors andidentifiedhypertension(15.4%)andcentralobesity(6.3%),aswellastheircombination(19.0%),asthemostcommon MetSriskfactors.Analyzingriskfactorflowoverthefive-yearfollow-up,wefoundthatmostindividualsremainedintheir riskfactorstateandthatlowhigh-densitylipoproteincholesterol(HDL)(6.3%)wasthemostprominentadditionalriskfactor beyondhypertensionandcentralobesity.AlsoamongindividualswithoutanyMetSriskfactoratbaseline,lowHDL(3.5%), hypertension(2.1%),andcentralobesity(1.6%)werethefirs