A Newly Identified Essential Complex, Dre2-Tah18, Controls Mitochondria Integrity and Cell Death after Oxidative Stress in Yeast 英文参考文献.docVIP

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A Newly Identified Essential Complex, Dre2-Tah18, Controls Mitochondria Integrity and Cell Death after Oxidative Stress in Yeast 英文参考文献.doc

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A Newly Identified Essential Complex, Dre2-Tah18, Controls Mitochondria Integrity and Cell Death after Oxidative Stress in Yeast 英文参考文献

ANewlyIdentifiedEssentialComplex,Dre2-Tah18, ControlsMitochondriaIntegrityandCellDeathafter OxidativeStressinYeast LaurenceVernis1*,Ce′lineFacca1,EmmanuelleDelagoutte1,NicolasSoler1,RolandChanet1 ,Bernard Guiard2,Ge′rardFaye3,GiuseppeBaldacci1 1Re′gulation de la re′plication de l’ADN des eucaryotes, UMR2027 CNRS/Institut Curie, INSERM, Universite′ Paris-Sud, Orsay, France, 2CNRS, Centre de Ge′ne′tique Mole′culaire,Gif-sur-Yvette,France,3Stabilite′ desge′nomes etstressge′notoxiques,UMR2027CNRS/InstitutCurie,Orsay,France Abstract AmutatedalleleoftheessentialgeneTAH18waspreviouslyidentifiedinourlaboratoryinageneticscreenfornewproteins interacting with the DNA polymerase delta in yeast [1]. The present work shows that Tah18 plays a role in response to oxidative stress. After exposure to lethal doses of H2O2, GFP-Tah18 relocalizes to the mitochondria and controls mitochondria integrity and cell death. Dre2, an essential Fe/S cluster protein and homologue of human anti-apoptotic Ciapin1,wasidentifiedasamolecularpartnerofTah18intheabsenceofstress.Moreover,Ciapin1isabletoreplaceyeast Dre2invivoandphysicallyinteractswithTah18.Ourresultsareinfavourofanoxidativestress-inducedcelldeathinyeast thatinvolvesmitochondriaandiscontrolledbythenewlyidentifiedDre2-Tah18complex. Citation:VernisL,FaccaC,DelagoutteE,SolerN,ChanetR,etal.(2009)ANewlyIdentifiedEssentialComplex,Dre2-Tah18,ControlsMitochondriaIntegrityand CellDeathafterOxidativeStressinYeast.PLoSONE4(2):e4376.doi:10.1371/journal.pone.0004376 Editor:MartinG.Marinus,UniversityofMassachusettsMedicalSchool,UnitedStatesofAmerica ReceivedOctober7,2008;AcceptedDecember25,2008;PublishedFebruary5,2009 Copyright: ? 2009 Vernis et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:ThisworkwassupportedfinanciallybyfrenchCNRS,INSERMandInstitutCurie.NSisareci