A NMDA Receptor Antagonist, MK-801 Impairs Consolidating Extinction of Auditory Conditioned Fear Responses in a Pavlovian Model 英文参考文献.docVIP

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A NMDA Receptor Antagonist, MK-801 Impairs Consolidating Extinction of Auditory Conditioned Fear Responses in a Pavlovian Model 英文参考文献.doc

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A NMDA Receptor Antagonist, MK-801 Impairs Consolidating Extinction of Auditory Conditioned Fear Responses in a Pavlovian Model 英文参考文献

ANMDAReceptorAntagonist,MK-801Impairs ConsolidatingExtinctionofAuditoryConditionedFear ResponsesinaPavlovianModel Jun-LiLiu1,2,3.,MinLi2.*,Xiao-RongDang4.,Zheng-HongWang1,Zhi-RenRao5,Sheng-XiWu4, Yun-QingLi4,WenWang4* 1DepartmentofTeachingandTraining,FourthMilitaryMedicalUniversity,Xi’an,People’sRepublicofChina,2DepartmentofPsychology,SchoolofNurse,ThirdMilitary MedicalUniversity,ChongQing,People’sRepublicofChina,3DepartmentofNursing,QingHaiHealthandProfessionalTechnologyCollege,XiNing,People’sRepublicof China, 4Department ofAnatomy,Histologyandembryology;K. K.Leung Brain ResearchCentre,Fourth MilitaryMedical University, Xi’an, People’s Republic of China, 5InstituteofNeuroscience,FourthMilitaryMedicalUniversity,Xi’an,People’sRepublicofChina Abstract Background:Inauditoryfearconditioning,repeatedpresentationofthetoneintheabsenceofshockleadstoextinctionof the acquired fear responses. The glutamate N-methyl-D-aspartate receptor (NMDAR) is thought to be involved in the extinction of the conditioned fear responses, but its detailed role in initiating and consolidating or maintaining the fear extinctionmemoryisunclear.HereweinvestigatedthisissuebyusingaNMDARantagonist,MK-801. Methods/MainFindings:Theeffectsofimmediate(beginningat10minaftertheconditioning)anddelayed(beginningat 24hafterconditioning)extinctionswerefirstcomparedwiththefindingthatdelayedextinctioncausedabetterandlong- lasting (still significant on the 20th day after extinction) depression on the conditioned fear responses. In a second experiment, MK-801 was intraperitoneally (i.p.) injected at 40min before, 4h or 12h after the delayed extinction, correspondingtocriticaltimepointsforinitiating,consolidatingormaintainingthefearextinctionmemory.i.p.injectionof MK-801ateither40minbeforeor4hafterdelayedextinctionresultedinanimpairmentofinitiatingandconsolidatingfear extinction memory, which caused a long lasting increased freezing score that was still significant on the 7th day after extinction, compared with