A Novel Group of Moraxella catarrhalis UspA Proteins Mediates Cellular Adhesion via CEACAMs and Vitronectin 英文参考文献.docVIP
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A Novel Group of Moraxella catarrhalis UspA Proteins Mediates Cellular Adhesion via CEACAMs and Vitronectin 英文参考文献
ANovelGroupofMoraxellacatarrhalisUspAProteins
MediatesCellularAdhesionviaCEACAMsandVitronectin
DarrylJ.Hill*,CherylWhittles,MumtazVirji*
SchoolofCellularMolecularMedicine,UniversityofBristol,Bristol,UnitedKingdom
Abstract
Moraxellacatarrhalis(Mx)isacommoncauseofotitismediaandexacerbationofchronicobstructivepulmonarydisease,an
increasingworldwideproblem.SurfaceproteinsUspA1andUspA2ofMxbindtoanumberofhumanreceptorsandmay
function in pathogenesis. Genetic recombination events in the pathogen can generate hybrid proteins termed UspA2H.
However,whethercertainkeyfunctions(e.g.UspA1-specificCEACAMbinding)canbeexchangedbetweentheseadhesin
familiesremainsunknown.Inthisstudy,wehaveshownthatMxcanincorporatetheUspA1CEACAM1-bindingregionnot
only into rare UspA1 proteins devoid of CEACAM-binding ability, but also into UspA2 which normally lack this capacity.
Further,ascreenofMxisolatesrevealedthepresenceofnovelUspA2Variantproteins(UspA2V)in,14%oftheCEACAM-
bindingpopulation.WedemonstratethattheexpressionofUspA2/2VwiththeCEACAM-bindingdomainenableMxtobind
both to cell surface CEACAMs and to integrins, the latter via vitronectin. Such properties of UspA2/2V have not been
reportedtodate.ThestudiesdemonstratethattheUspAfamilyismuchmoreheterogeneousthanpreviouslybelievedand
illustratetheinvivopotentialforexchangeoffunctionalregionsbetweenUspAproteinswhichcouldconveynoveladhesive
functionswhilstenhancingimmuneevasion.
Citation:HillDJ,WhittlesC,VirjiM(2012)ANovelGroupofMoraxellacatarrhalisUspAProteinsMediatesCellularAdhesionviaCEACAMsandVitronectin.PLoS
ONE7(9):e45452.doi:10.1371/journal.pone.0045452
Editor:MikaelSkurnik,UniversityofHelsinki,Finland
ReceivedJune8,2012;AcceptedAugust22,2012;PublishedSeptember25,2012
Copyright:?2012Hilletal.Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense,whichpermitsunrestricted
use,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited.
Funding: Thestudy was supported by agrant fro
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