A Replication Study of the Association between Rheumatoid Arthritis and Deletion of the Late Cornified Envelope Genes LCE3B and LCE3C 英文参考文献.docVIP

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A Replication Study of the Association between Rheumatoid Arthritis and Deletion of the Late Cornified Envelope Genes LCE3B and LCE3C 英文参考文献.doc

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A Replication Study of the Association between Rheumatoid Arthritis and Deletion of the Late Cornified Envelope Genes LCE3B and LCE3C 英文参考文献

AReplicationStudyoftheAssociationbetween RheumatoidArthritisandDeletionoftheLateCornified EnvelopeGenesLCE3BandLCE3C JudithG.M.Bergboer1,Masˇa Umic′evic′-Mirkov2,JaapFransen3,MartindenHeijer4,BarbaraFranke2, PietL.C.M.vanRiel3,JoostSchalkwijk1,MariekeJ.H.Coenen2*,onbehalfoftheNijmegenBiomedical Studyprincipalinvestigators 1DepartmentofDermatology,RadboudUniversityNijmegenMedicalCentre,NijmegenCentreforMolecularLifeSciences,Nijmegen,TheNetherlands,2Departmentof Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, 3Department of Rheumatology, Radboud University Nijmegen Medical Centre,Nijmegen,TheNetherlands,4DepartmentofEndocrinologyandDepartmentofEpidemiologyandBiostatistics,RadboudUniversityNijmegenMedicalCentre, Nijmegen,TheNetherlands Abstract Objective:Tworecentstudies,inaSpanishandaChinesepopulation,pointtoanassociationbetweenrheumatoidarthritis (RA)riskandthedeletionoftheLateCornifiedEnvelope(LCE)3Band3Cgenes(LCE3C_LCE3B-del),aknownriskfactorfor psoriasis.WeaimedtoreplicatethesestudiesinalargeDutchcohort. Methods:1039RAcasesand759controlsweregenotypedforLCE3C_LCE3B-del.Associationanalysiswasperformedforthe completecohortandafterstratificationfortheserologicmarkersanti-cycliccitrullinatedpeptideandrheumatoidfactor.A meta-analysiswasperformedcombiningourdatawiththeSpanishandChinesedatasets,resultinginananalysisincluding 2466RAcasesand2438controls. Results: In the Dutch cohort we did not observe a significant association of LCE3C_LCE3B-del (p=0.093) with RA risk. A stratifiedanalysisfortheserologicpositiveandnegativegroupdidnotshowanassociationbetweenthegeneticvariant and disease risk, either. The meta-analysis, however, confirmed a significant association (p,0.0001, OR=1.31, 95% confidenceinterval1.16–1.47). Conclusion:Ourmeta-analysisconfirmstheassociationoftheLCE3deletionwithRA,suggestingthatLCE3C_LCE3B-delisa commonriskfactorfor(auto)immunediseases. Citation:BergboerJGM,Umic′evic′-MirkovM,FransenJ,denHeijerM,FrankeB,etal.(2