A Small Genomic Region Containing Several Loci Required for Gastrulation in Drosophila 英文参考文献.docVIP

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A Small Genomic Region Containing Several Loci Required for Gastrulation in Drosophila 英文参考文献.doc

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A Small Genomic Region Containing Several Loci Required for Gastrulation in Drosophila 英文参考文献

ASmallGenomicRegionContainingSeveralLoci RequiredforGastrulationinDrosophila SamJ.Mathew1,StephenKerridge2,MariaLeptin1* 1InstituteofGenetics,UniversityofCologne,Cologne,Germany,2IBDML-UMR6216,Case907ParcScientifiquedeLuminy,Marseille,France Abstract GeneticscreensinDrosophiladesignedtosearchforlociinvolvedingastrulationhaveidentifiedfourregionsofthegenome thatarerequiredzygoticallyfortheformationoftheventralfurrow.Forthreeofthese,thegenesresponsibleforthemutant phenotypeshavebeenfound.Wenowdescribeageneticcharacterizationofthefourthregion,whichencompassesthe cytogeneticinterval24C3-25B,andthemappingofgenesinvolvedingastrulationinthisregion.Wehavedeterminedthe precisebreakpointsofseveralexistingdeficienciesandhavegeneratednewdeficiencies.Ourresultsshowthattheregion containsatleastthreedifferentlociassociatedwithgastrulationeffects.Onematernaleffectgeneinvolvedinventralfurrow formation maps at 24F but could not be identified. For asecond maternal effect gene which is required for germ band extension, we identify a candidate gene, CG31660, which encodes a G protein coupled receptor. Finally, one gene acts zygoticallyinventralfurrowformationandweidentifyitasTraf4. Citation:MathewSJ,KerridgeS,LeptinM(2009)ASmallGenomicRegionContainingSeveralLociRequiredforGastrulationinDrosophila.PLoSONE4(10):e7437. doi:10.1371/journal.pone.0007437 Editor:SuzannahRutherford,FredHutchinsonCancerResearchCenter,UnitedStatesofAmerica ReceivedJune26,2009;AcceptedSeptember7,2009;PublishedOctober13,2009 Copyright: ? 2009 Mathew et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:SJMwassupportedbyafellowshipfromtheNRWGraduateSchoolofGeneticsandFunctionalGenomics.Thisworkwassupportedbygrantsfromthe DeutscheForschungsgemeinschaft(SFB635).Thefundershadnoroleinstudydesign,datacollectionandanalysis,decisiontopublish,