A Systems Biology Approach Identifies Molecular Networks Defining Skeletal Muscle Abnormalities in Chronic Obstructive Pulmonary Disease 英文参考文献.docVIP

下载本文档

1
0
约6.76万字
约 16页
2017-05-11 发布于上海
举报
版权申诉

A Systems Biology Approach Identifies Molecular Networks Defining Skeletal Muscle Abnormalities in Chronic Obstructive Pulmonary Disease 英文参考文献.doc

1、本文档共16页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

A Systems Biology Approach Identifies Molecular Networks Defining Skeletal Muscle Abnormalities in Chronic Obstructive Pulmonary Disease 英文参考文献

ASystemsBiologyApproachIdentifiesMolecular NetworksDefiningSkeletalMuscleAbnormalitiesin ChronicObstructivePulmonaryDisease NilTuran1,SusanaKalko2,AnnaStincone1,KimClarke1,AyeshaSabah1,KatherineHowlett3,S.John Curnow3,DiegoA.Rodriguez2,MartaCascante4,LauraO’Neill3,StuartEgginton3,JosepRoca2, FrancescoFalciani1* 1SchoolofBiosciences,UniversityofBirmingham,Birmingham,UnitedKingdom,2HospitalCl?′nic,Institutd’InvestigacionsBiome`diques AugustPiiSunyer(IDIBAPS), (CIBERES), University of Barcelona, Barcelona, Spain, 3Institute of Biomedical Research, School of Immunity and Infection, College of Medical and Dental Sciences, UniversityofBirmingham,Birmingham,UnitedKingdom,4DepartmentofBiochemistry andMolecularBiology,BiologyFaculty,UniversitatdeBarcelona,Biomedicine InstitutefromUniversitatdeBarcelona(IBUB),Barcelona,Catalonia,Spain Abstract ChronicObstructivePulmonaryDisease(COPD)isaninflammatoryprocessofthelunginducingpersistentairflowlimitation. Extensive systemic effects, such as skeletal muscle dysfunction, often characterize these patients and severely limit life expectancy.Despiteconsiderableresearchefforts,themolecularbasisofmuscledegenerationinCOPDisstillamatterof intense debate. In this study, we have applied a network biology approach to model the relationship between muscle molecularandphysiologicalresponsetotrainingandsystemicinflammatorymediators.Ourmodelshowsthatfailuretoco- ordinately activate expression of several tissue remodelling and bioenergetics pathways is a specific landmark of COPD diseasedmuscles.Ourfindingsalsosuggestthatthisphenomenonmaybelinkedtoanabnormalexpressionofanumberof histone modifiers, which we discovered correlate with oxygen utilization. These observations raised the interesting possibilitythatcellhypoxiamaybeakeyfactordrivingskeletalmuscledegenerationinCOPDpatients. Citation: Turan N, Kalko S, Stincone A, Clarke K, Sabah A, et al. (2011) A Systems Biology Approach Identifies Molecular Networks Defining Skeletal Muscle