CompactRepresentationofProtein.PDFVIP

Compact Representation of Protein Surface Patches Mohammed AlQuraishi Introduction Prediction of protein structure from amino acid (AA) sequence is one of the grand challenges of modern biochemistry. While ab initio structure prediction is difficult, prediction of local structure is more tractable if experimentally determined structures of homologous proteins exist. The prediction of local patches is useful in predicting interaction partners of proteins and nucleic acids. The high-dimensionality of this problem has so far prevented machine learning methods from making