Figure6.1SolutionpHasafunctionofconcentrationfora.pptVIP

Figure 6.1 Solution pH as a function of concentration for a basic salt. Figure 6.2 Solution pH as a function of concentration for an acidic salt. Figure 6.3 Percentage of salt formed as a function of acid pKa when reacted with a basic drug of pKa 7.5. Figure 6.4 A decision tree for salt selection based on characterisation of physicochemical properties (data from Morris et al. (1994)). Figure 6.5 Solubility profile for a basic salt as a function of pH (pKa 6.7). Figure 6.6 Solubility profile for an acidic salt as a function of pH (pKa 5.6). Figure 6.7 Solubility profil