Activated TLR Signaling in Atherosclerosis among Women with Lower Framingham Risk Score The Multi-Ethnic Study of Atherosclerosis 英文参考文献.docVIP

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Activated TLR Signaling in Atherosclerosis among Women with Lower Framingham Risk Score The Multi-Ethnic Study of Atherosclerosis 英文参考文献.doc

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Activated TLR Signaling in Atherosclerosis among Women with Lower Framingham Risk Score The Multi-Ethnic Study of Atherosclerosis 英文参考文献

ActivatedTLRSignalinginAtherosclerosisamong WomenwithLowerFraminghamRiskScore:TheMulti- EthnicStudyofAtherosclerosis Chiang-ChingHuang1*,KiangLiu1,RichardM.Pope2,PanDu3,SimonLin3,NaliniM.Rajamannan4, Qi-QuanHuang2,NaderehJafari5,GregoryL.Burke6,WendyPost7,KarolE.Watson8,CraigJohnson9, MarthaL.Daviglus1,DonaldM.Lloyd-Jones1,4 1Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America, 2Rheumatology Division, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America, 3Bioinformatics Core, Feinberg School of Medicine, Northwestern University,Chicago, Illinois,United StatesofAmerica, 4Cardiology Division, DepartmentofMedicine,FeinbergSchool ofMedicine,NorthwesternUniversity, Chicago, Illinois,UnitedStatesofAmerica,5GenomicsCore,FeinbergSchoolofMedicine,NorthwesternUniversity,Chicago,Illinois,UnitedStatesofAmerica,6DivisionofPublic HealthSciences,WakeForestUniversityHealthSciences,Winston-Salem,NorthCarolina,UnitedStatesofAmerica,7JohnsHopkinsUniversity,Baltimore,Maryland,United States of America, 8Division of Cardiology, UCLA School of Medicine, Los Angeles, California, United States of America, 9Collaborative Health Studies Coordinating Center,UniversityofWashington,Seattle,Washington,UnitedStatesofAmerica Abstract Background: Atherosclerosis is the leading cause of cardiovascular disease (CVD). Traditional risk factors can be used to identifyindividualsathighriskfordevelopingCVDandaregenerallyassociatedwiththeextentofatherosclerosis;however, substantialnumbersofindividualsatloworintermediateriskstilldevelopatherosclerosis. Results: A case-control study was performed using microarray gene expression profiling of peripheral blood from 119 healthywomenintheMulti-EthnicStudyofAtherosclerosiscohortaged50orabove.Allparticipantshadlow(,10%)to intermediate(10%to20%)predictedFraminghamrisk;cases(N=48)hadcoronaryarterycalcium(CAC)score.100and carotidintima-me