Active Chronic Sarcoidosis is Characterized by Increased Transitional Blood B Cells, Increased IL-10-Producing Regulatory B Cells and High BAFF Levels 英文参考文献.docVIP

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Active Chronic Sarcoidosis is Characterized by Increased Transitional Blood B Cells, Increased IL-10-Producing Regulatory B Cells and High BAFF Levels 英文参考文献.doc

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Active Chronic Sarcoidosis is Characterized by Increased Transitional Blood B Cells, Increased IL-10-Producing Regulatory B Cells and High BAFF Levels 英文参考文献

ActiveChronicSarcoidosisisCharacterizedbyIncreased TransitionalBloodBCells,IncreasedIL-10-Producing RegulatoryBCellsandHighBAFFLevels AnneSaussine1,2,3,AbdellatifTazi4,Se′verineFeuillet4,MichelRybojad3,CarolineJuillard3, AnneBergeron4,Vale′rieDessirier1,2,FatihaBouhidel5,6,AnneJanin5,6,ArmandBensussan1,2*, MartineBagot1,2,3.,Jean-DavidBouaziz 1,2,3 . * 1INSERMU976,Paris,France,2Universite′ParisDiderot,SorbonneParisCite′,LaboratoryofImmunology,DermatologyOncology,UMR-S976,Paris,France,3Servicede Dermatologie,Ho?pitalSaintLouis,Paris,France,4Universite′ParisDiderot,SorbonneParisCite′;AP-HP;ServicedePneumologie,Ho?pitalSaintLouis,Paris,France,5Service d’Anatomopathologie,Ho?pitalSaintLouis,Paris,France,6Universite′ ParisDiderotSorbonneParisCite′,LaboratoryofPahology,UMR-S728,Paris,France Abstract Background: Sarcoidosis is a multisystemic disease of unknown etiology characterized by a disproportionate Th1 granulomatousimmuneresponseintheorgansinvolved.PlasmatichypergammaglobulinemiaandBcellaccumulationin granulomatous lesions suggest the possible role of humoral immune responses in the pathogenesis of sarcoidosis. The purposeofthisstudyistodescribeBcellperipheralcompartmentinsarcoidosis. Methodology/PrincipalFindings:WeanalyzedbloodBcellsubsetsandBAFFlevelsin33patientswithchronicsarcoidosis (active sarcoidosis n=18; inactive sarcoidosis n=15) and 18 healthy donors. Active chronic sarcoidosis patients had significantlylesscirculatingmemoryBcells(p,0.01),moretransitional(p,0.01)andincreasednumbersofIL-10-producing regulatoryBcells(p,0.05)comparedwithhealthydonorsandpatientswithinactivesarcoidosis.BAFFserumlevelswere significantlyhigherinpatientswithactivesarcoidosis(p,0.01versushealthydonorsandinactivesarcoidosispatients)and strongly correlated with serum hypergammaglobulinemia (r=0.53, p,0.01) and angiotensin converting enzyme levels (r=0.61,p=,0.01). Conclusions/Significance: These data show that there is an altered B cell homeostasis in active sarcoidosis and su