Acute Effects of Nicotine Amplify Accumbal Neural Responses during Nicotine-Taking Behavior and Nicotine-Paired Environmental Cues 英文参考文献.docVIP

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Acute Effects of Nicotine Amplify Accumbal Neural Responses during Nicotine-Taking Behavior and Nicotine-Paired Environmental Cues 英文参考文献.doc

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Acute Effects of Nicotine Amplify Accumbal Neural Responses during Nicotine-Taking Behavior and Nicotine-Paired Environmental Cues 英文参考文献

AcuteEffectsofNicotineAmplifyAccumbalNeural ResponsesduringNicotine-TakingBehaviorand Nicotine-PairedEnvironmentalCues KarineGuillem1,2*,LauraL.Peoples3,4 * 1Universite′ de Bordeaux, Institut des Maladies Neurode′ge′ne′ratives, Bordeaux, France, 2Centre National de la Recherche Scientifique, Institut des Maladies Neurode′ge′ne′ratives,Bordeaux,France,3DepartmentofPsychiatry,UniversityofPennsylvaniaSchoolofMedicine,Philadelphia,Pennsylvania,UnitedStatesofAmerica, 4DepartmentofPharmacologyandPhysiology,DrexelUniversityCollegeofMedicine,Philadelphia,Pennsylvania,UnitedStatesofAmerica Abstract Nicotineself-administration(SA)ismaintainedbyseveralvariables,includingthereinforcingpropertiesofnicotine-paired cues and the nicotine-induced amplification of those cue properties. The nucleus accumbens (NAc) is implicated in mediatingtheinfluenceofthesevariables,thoughtheunderlyingneurophysiologicalmechanismsarenotyetunderstood. Inthepresentstudy,Long-Evansratsweretrainedtoself-administernicotine.DuringSAsessionseachpressofaleverwas followedbyanintravenousinfusionofnicotine(30mg/kg)pairedwithacombinedlight-tonecue.Extracellularrecordings of single-neuron activity showed that 20% of neurons exhibited a phasic change in firing during the nicotine-directed operant,thelight-tonecue,orboth.Thephasicchangeinfiringfor98%ofneuronswasanincrease.Sixty-twopercentof NAcneuronsadditionallyoralternativelyshowedasustaineddecreaseinaveragefiringduringtheSAsessionrelativetoa presessionbaseline period.Thesesession decreases infiring weresignificantly lessprevalent inagroupof neuronsthat were activated during either the operant or the cue than in a group of neurons that were nonresponsive during those events(referredtoastask-activatedandtask-nonactivatedneurons,respectively).Moreover,thesessiondecreaseinfiring was dose-dependent for only the task-nonactivated neurons. The data of the present investigation provide supportive correlational evidence for two hypotheses: (1) excitatory neurophysi