An X Chromosome Association Scan of the Norfolk Island Genetic Isolate Provides Evidence for a Novel Migraine Susceptibility Locus at Xq12 英文参考文献.docVIP
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An X Chromosome Association Scan of the Norfolk Island Genetic Isolate Provides Evidence for a Novel Migraine Susceptibility Locus at Xq12 英文参考文献
AnXChromosomeAssociationScanoftheNorfolkIsland
GeneticIsolateProvidesEvidenceforaNovelMigraine
SusceptibilityLocusatXq12
BridgetH.Maher1,RodA.Lea1,MilesBenton1,HannahC.Cox1,ClaireBellis1,2,MelanieCarless2,
ThomasD.Dyer2,JoanneCurran2,JacC.Charlesworth2,3,JulieE.Buring4,TobiasKurth4,6,7,
DanielI.Chasman4,5,PaulMRidker4,5,MarkusSchu¨rks4,6,JohnBlangero2,LynR.Griffiths1*
1 Genomics Research Centre, Griffith Health Institute, Griffith University, Queensland, Australia, 2 Department of Genetics, Texas Biomedical Research Institute, San
Antonio, Texas, United States of America,3 Menzies Research Institute Tasmania, Hobart, Tasmania, Australia,4 Division of Preventive Medicine, Department of Medicine,
Harvard Medical School, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America, 5 Donald W. Reynolds Center for Cardiovascular Disease
Prevention, Harvard Medical School, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America,6 Department of Neurology, University Hospital
Essen, Essen, Germany,7 INSERM Unit 708 - Neuroepidemiology, Paris, France
Abstract
Migraine is a common and debilitating neurovascular disorder with a complex envirogenomic aetiology. Numerous studies
have demonstrated a preponderance of women affected with migraine and previous pedigree linkage studies in our
laboratory have identified susceptibility loci on chromosome Xq24-Xq28. In this study we have used the genetic isolate of
Norfolk Island to further analyse the X chromosome for migraine susceptibility loci. An association approach was
employed to analyse 14,124 SNPs spanning the entire X chromosome. Genotype data from 288 individuals comprising a
large core-pedigree, of which 76 were affected with migraine, were analysed. Although no SNP reached chromosome-wide
significance (empiricala = 161025) ranking by P-value revealed
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