Analysis of Behavior and Trafficking of Dendritic Cells within the Brain during Toxoplasmic Encephalitis 英文参考文献.docVIP
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Analysis of Behavior and Trafficking of Dendritic Cells within the Brain during Toxoplasmic Encephalitis 英文参考文献
AnalysisofBehaviorandTraffickingofDendriticCells
withintheBrainduringToxoplasmicEncephalitis
BeenaJohn1,BrendonRicart2,EliaD.TaitWojno1,TajieH.Harris1,LouiseM.Randall1,DavidA.
Christian1,BethGregg1,DanielManzoniDeAlmeida1,WolfgangWeninger3,DanielA.Hammer2,
ChristopherA.Hunter1*
1Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, 2Chemical and
Biomolecular Engineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, 3The Centenary Institute for Cancer Medicine and Cell
Biology,Newtown,Australia
Abstract
Undernormalconditionstheimmunesystemhaslimitedaccesstothebrain;however,duringtoxoplasmicencephalitis(TE),
largenumbersofTcellsandAPCsaccumulatewithinthissite.Acombinationofrealtimeimaging,transgenicreportermice,
andrecombinantparasitesallowedacomprehensiveanalysisofCD11c+cellsduringTE.ThesestudiesrevealthattheCNS
+
CD11c cellsconsistofamixtureofmicrogliaanddendriticcells(DCs)withdistinctbehaviorassociatedwiththeirabilityto
interactwithparasitesoreffectorTcells.TheCNSDCsupregulated severalchemokinereceptors duringTE,butnoneof
theseindividualreceptorstestedwasrequiredformigrationofDCsintothebrain.However,thisprocesswaspertussistoxin
sensitive and dependent on the integrin LFA-1, suggesting that the synergistic effect of signaling through multiple
chemokinereceptors,possiblyleadingtochangesintheaffinityofLFA-1,isinvolvedintherecruitment/retentionofDCsto
theCNSandthusprovidesnewinsightsintohowtheimmunesystemaccessesthisuniquesite.
Citation: John B, Ricart B, Tait Wojno ED, Harris TH, Randall LM, et al. (2011) Analysis of Behavior and Trafficking of Dendritic Cells within the Brain during
ToxoplasmicEncephalitis.PLoSPathog7(9):e1002246.doi:10.1371/journal.ppat.1002246
Editor:L.DavidSibley,WashingtonUniversitySchoolofMedicine,UnitedStatesofAmerica
ReceivedApril21,2011;AcceptedJuly20,2011;PublishedSeptember15,2011
Copyright: ? 2011 John et al. Thi
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