Antibacterial Activity and Mechanism of a Scorpion Venom Peptide Derivative In Vitro and In Vivo 英文参考文献.docVIP
- 1、本文档共11页,可阅读全部内容。
- 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
- 5、该文档为VIP文档,如果想要下载,成为VIP会员后,下载免费。
- 6、成为VIP后,下载本文档将扣除1次下载权益。下载后,不支持退款、换文档。如有疑问请联系我们。
- 7、成为VIP后,您将拥有八大权益,权益包括:VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 8、VIP文档为合作方或网友上传,每下载1次, 网站将根据用户上传文档的质量评分、类型等,对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
Antibacterial Activity and Mechanism of a Scorpion Venom Peptide Derivative In Vitro and In Vivo 英文参考文献
AntibacterialActivityandMechanismofaScorpion
VenomPeptideDerivativeInVitroandInVivo
LuyangCao.,ChaoDai.,ZhongjieLi,ZhengFan,YuSong,YingliangWu,ZhijianCao*,WenxinLi*
StateKeyLaboratoryofVirology,CollegeofLifeSciences,WuhanUniversity,Wuhan,P.R.China
Abstract
BmKn2isanantimicrobialpeptide(AMP)characterized fromthevenomofscorpion MesobuthusmartensiiKarschbyour
group.Inthisstudy,Kn2-7wasderivedfromBmKn2toimprovetheantibacterialactivityanddecreasehemolyticactivity.
Kn2-7showedincreasedinhibitoryactivityagainstbothGram-positivebacteriaandGram-negativebacteria.Moreover,Kn2-
7exhibitedhigherantibacterialactivityagainstclinicalantibiotic-resistantstrainssuchasmethicillin-resistantStaphylococcus
aureus (MRSA). In addition, thetopical use of Kn2-7 effectively protected theskin of mice from infection in an S. aureus
mouseskininfectionmodel.Kn2-7exerteditsantibacterialactivityviaabactericidalmechanism.Kn2-7killedS.aureusandE.
colirapidlybybindingtothelipoteichoicacid(LTA)intheS.aureuscellwallandthelipopolysaccharides(LPS)intheE.coli
cellwall,respectively.Finally,thehemolyticactivityofKn2-7wassignificantlydecreased,comparedtothewild-typepeptide
BmKn2.Takentogether,theKn2-7peptidecanbedevelopedasatopicaltherapeuticagentfortreatingbacterialinfections.
Citation:CaoL,DaiC,LiZ,FanZ,SongY,etal.(2012)AntibacterialActivityandMechanismofaScorpionVenomPeptideDerivativeInVitroandInVivo .PLoS
ONE7(7):e40135.doi:10.1371/journal.pone.0040135
Editor:PauloLeeHo,InstitutoButantan,Brazil
ReceivedApril24,2012;AcceptedJune4,2012;PublishedJuly5,2012
Copyright:?2012Caoetal.Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense,whichpermitsunrestricted
use,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited.
Funding:ThisworkwassupportedbygrantsfromNaturalScienceFoundationofChina(NSFC)(No,theChinaSpecificProjectforDevelopingNew
Drugs (Nos. 2009ZX09103-612 and 2011ZX09102-001-32), and the National Basic Research Program o
您可能关注的文档
- Annexin A2 Binds RNA and Reduces the Frameshifting Efficiency of Infectious Bronchitis Virus 英文参考文献.doc
- Annual Risk of Tuberculous Infection Using Different Methods in Communities with a High Prevalence of TB and HIV in Zambia and South Africa 英文参考文献.doc
- Annotation Marathon Validates 21,037 Human Genes 英文参考文献.doc
- Anopheles gambiae Antiviral Immune Response to Systemic O'nyong-nyong Infection 英文参考文献.doc
- Anopheles Immune Genes and Amino Acid Sites Evolving Under the Effect of Positive Selection 英文参考文献.doc
- Ant Queen Egg-Marking Signals Matching Deceptive Laboratory Simplicity with Natural Complexity 英文参考文献.doc
- Annotation of Two Large Contiguous Regions from the Haemonchus contortus Genome Using RNA-seq and Comparative Analysis with Caenorhabditis elegans 英文参考文献.doc
- Anode Biofilm Transcriptomics Reveals Outer Surface Components Essential for High Density Current Production in Geobacter sulfurreducens Fuel Cells 英文参考文献.doc
- Anomalous Surplus Energy Transfer Observed with Multiple FRET Acceptors 英文参考文献.doc
- Antagonism between DNA and H3K27 Methylation at the Imprinted Rasgrf1 Locus 英文参考文献.doc
文档评论(0)