Antifungal Activity of Resveratrol against Botrytis cinerea Is Improved Using 2-Furyl Derivatives 英文参考文献.docVIP

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Antifungal Activity of Resveratrol against Botrytis cinerea Is Improved Using 2-Furyl Derivatives 英文参考文献.doc

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Antifungal Activity of Resveratrol against Botrytis cinerea Is Improved Using 2-Furyl Derivatives 英文参考文献

AntifungalActivityofResveratrolagainstBotrytis cinereaIsImprovedUsing2-FurylDerivatives FrancescoCaruso1*,LeonoraMendoza2,PauloCastro2,MilenaCotoras2,MariaAguirre2 ,Betty Matsuhiro2,MauricioIsaacs3,MiriamRossi4*,AngelaViglianti5,RobertoAntonioletti1 1IstitutodiChimicaBiomolecolare,ConsiglioNazionaledelleRicerche,UniversityofRome,IstitutoChimico,Rome,Italy,2FacultaddeQu?′micayBiolog?′a,Universidadde SantiagodeChile,Santiago,Chile,3FacultaddeCiencias,DepartamentodeQu?′mica,UniversidaddeChile,Santiago,Chile,4VassarCollege,DepartmentofChemistry, Poughkeepsie,NewYork,UnitedStatesofAmerica,5UniversityofRome,IstitutoChimico,Rome,Italy Abstract Theantifungaleffectofthreefurylcompoundscloselyrelatedtoresveratrol,(E)-3,4,5-trimethoxy-b-(2-furyl)-styrene(1 ),(E)- 4-methoxy-b-(2-furyl)-styrene (2) and (E)-3,5-dimethoxy-b-(2-furyl)-styrene (3) against Botrytis cinerea was analyzed. The inhibitoryeffect,at100mgml21ofcompounds1,2,3andresveratrolonconidiagermination,wasdeterminedtobeabout 70%,whileatthesameconcentrationpterostilbene(adimethoxylderivativeofresveratrol)producedcompleteinhibition. Thetitlecompoundsweremorefungitoxictowardsinvitromycelialgrowththanresveratrolandpterostilbene.Compound 3wasthemostactiveandapotentialexplanationofthisfeatureisgivenusingdensityfunctionaltheory(DFT)calculations onthedemethoxylation/demethylationprocess.Compound3wasfurtherevaluatedforitseffectsonlaccaseproduction, oxygenconsumptionandmembraneintegrityofB.cinerea.Anincreaseofthelaccaseactivitywasobservedinthepresence of compound 3 and, using Sytox Green nucleic acid stain, it was demonstrated that this compound altered B. cinerea membrane.Finally,compound3partiallyaffectedconidiarespiration. Citation:CarusoF,MendozaL,CastroP,CotorasM,AguirreM,etal.(2011)AntifungalActivityofResveratrolagainstBotrytiscinereaIsImprovedUsing2-Furyl Derivatives.PLoSONE6(10):e25421.doi:10.1371/journal.pone.0025421 Editor:MatthewH.Todd,UniversityofSydney,Australia ReceivedJanuary28,2011;AcceptedSeptember5,2011;Publ