Associations among RaceEthnicity, ApoC-III Genotypes, and Lipids in HIV-1-Infected Individuals on Antiretroviral Therapy 英文参考文献.docVIP

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Associations among RaceEthnicity, ApoC-III Genotypes, and Lipids in HIV-1-Infected Individuals on Antiretroviral Therapy 英文参考文献.doc

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Associations among RaceEthnicity, ApoC-III Genotypes, and Lipids in HIV-1-Infected Individuals on Antiretroviral Therapy 英文参考文献

o PL SMEDICINE AssociationsamongRace/Ethnicity,ApoC-III Genotypes,andLipidsinHIV-1-Infected IndividualsonAntiretroviralTherapy Andrea S.Foulkes1*,David A.Wohl2,Ian Frank3,Elaine Puleo1,Stephanie Restine3,Megan L.Wolfe3,Michael P.Dube4, Pablo Tebas3,Muredach P.Reilly3 1SchoolofPublicHealthandHealthSciences,UniversityofMassachusetts,Amherst,Massachusetts,UnitedStatesofAmerica,2UniversityofNorthCarolina,ChapelHill, North Carolina, United States of America, 3 School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, 4 Indiana University, Indianapolis,Indiana,UnitedStatesofAmerica CompetingInterests:Theauthors havedeclaredthatnocompeting interestsexist. ABSTRACT Background AuthorContributions:ASF,DAW, IF,MPD,PT,andMPRdesignedthe study.ASFandEPperformed statisticalanalysisofthedata.MPD enrolledpatients.ASF,DAW,IF, MPD,PT,andMPRcontributedto writingthepaper.ASF,IFandMPR werecoauthorsofasuccessfulgrant applicationthatsecuredfundsto supportthedataanalysis.SRand MLWdevelopedassaysfortheSNP genotyping,performedtheSNP genotypingexperimentsforthe study,andanalyzedtheresulting scatterplots. Protease inhibitors (PIs) are associated with hypertriglyceridemia and atherogenic dyslipidemia. Identifying HIV-1-infected individuals who are at increased risk of PI-related dyslipidemiawillfacilitatetherapeuticchoicesthatmaintainviralsuppressionwhilereducing riskofatheroscleroticdiseases.ApolipoproteinC-III(apoC-III)genevariants,whichvarybyrace/ ethnicity, have been associated with a lipid profile that resembles PI-induced dyslipidemia. However,theassociationofrace/ethnicity,orcandidategeneeffectsacrossrace/ethnicity,with plasmalipidlevelsinHIV-1-infectedindividuals,hasnotbeenreported. MethodsandFindings A cross-sectional analysis of race/ethnicity, apoC-III/apoA-I genotypes, and PI exposure on plasmalipidswasperformedinAIDSClinicalTrialGroupstudies(n?626).Race/ethnicitywasa highlysignificantpredictorofplasmalipidsinfullyadjustedmodels.Fu