Balancing Robustness against the Dangers of Multiple Attractors in a Hopfield-Type Model of Biological Attractors 英文参考文献.docVIP

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Balancing Robustness against the Dangers of Multiple Attractors in a Hopfield-Type Model of Biological Attractors 英文参考文献.doc

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Balancing Robustness against the Dangers of Multiple Attractors in a Hopfield-Type Model of Biological Attractors 英文参考文献

BalancingRobustnessagainsttheDangersofMultiple AttractorsinaHopfield-TypeModelofBiological Attractors RonC.Anafi1,JasonH.T.Bates2* 1Division of Sleep Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, 2Department of Medicine, University of Vermont, Burlington,Vermont,UnitedStatesofAmerica Abstract Background:Manychronichumandiseasesareofunclearorigin,andpersistlongbeyondanyknowninsultorinstigating factor.Thesediseasesmayrepresentastructurallynormalbiologicnetworkthathasbecometrappedwithinthebasinofan abnormalattractor. Methodology/PrincipalFindings:WeusedtheHopfieldnetasthearchetypicalexampleofadynamicbiologicalnetwork. ByprogressivelyremovingthelinksoffullyconnectedHopfieldnets,wefoundthatadesignatedattractorofthenetscould stillbesupporteduntilonlyslightlymorethan1linkpernoderemained.Asthenumberoflinksapproachedthisminimum value,therateofconvergencetothisattractorfromanarbitrarystartingstateincreaseddramatically.Furthermore,with morethanabouttwicetheminimumoflinks,thenetbecameincreasinglyabletosupportasecondattractor. Conclusions/Significance: We speculate that homeostatic biological networks may have evolved to assume a degree of connectivitythatbalancesrobustnessandagilityagainstthedangersofbecomingtrappedinanabnormalattractor. Citation:AnafiRC,BatesJHT(2010)BalancingRobustnessagainsttheDangersofMultipleAttractors inaHopfield-TypeModelofBiologicalAttractors.PLoS ONE5(12):e14413.doi:10.1371/journal.pone.0014413 Editor:JeanPeccoud,VirginiaTech,UnitedStatesofAmerica ReceivedApril27,2010;AcceptedDecember6,2010;PublishedDecember22,2010 Copyright: ? 2010 Anafi, Bates. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding: The authors acknowledge the financial support of an American Sleep Medicine Physician Scientist grant and the NIH (NCRR COBRE RR