Biocompatibility and Biodegradation Studies of Subconjunctival Implants in Rabbit Eyes 英文参考文献.docVIP

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Biocompatibility and Biodegradation Studies of Subconjunctival Implants in Rabbit Eyes 英文参考文献.doc

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Biocompatibility and Biodegradation Studies of Subconjunctival Implants in Rabbit Eyes 英文参考文献

BiocompatibilityandBiodegradationStudiesof SubconjunctivalImplantsinRabbitEyes YanPeng1.,MarcusAng2,3.,SelinFoo3,WingSumLee2,ZhenMa3,SubbuS.Venkatraman1*,TinaT. Wong1,2,3,4 * 1School of Materials Science and Engineering, Nanyang Technological University, Singapore, Singapore, 2Singapore National Eye Centre, Singapore, Singapore, 3SingaporeEyeResearchInstitute,Singapore,Singapore,4DepartmentofOphthalmology,YongYooLinSchoolofMedicine,NationalUniversityofSingapore,Singapore, Singapore Abstract Sustainedoculardrugdeliveryisdifficulttoachieve.Mostdrugshavepoorpenetrationduetothemultiplephysiological barriersoftheeyeandarerapidlyclearedifappliedtopically.Biodegradablesubconjunctivalimplantswithcontrolleddrug releasemaycircumventthesetwoproblems.Inourstudy,twomicrofilms(poly[d,l-lactide-co-glycolide]PLGAandpoly[d,l- lactide-co-caprolactone] PLC were developed and evaluated for their degradation behavior in vitro and in vivo. We also evaluated the biocompatibility of both microfilms. Eighteen eyes (9 rabbits) were surgically implanted with one type of microfilmineacheye.Serialanterior-segmentopticalcoherencetomography(AS-OCT)scanstogetherwithserialslit-lamp microscopy allowed us to measure thickness and cross-sectional area of the microfilms. In vitro studies revealed bulk degradation kinetics for both microfilms, while in vivo studies demonstrated surface erosion kinetics. Serial slit-lamp microscopyrevealednosignificantinflammationorvascularizationinbothtypesofimplants(meanincreaseinvascularity gradePLGA50/501260.5%vs.PLC70/301560.6%;P=0.91)overaperiodof6months.Histology,immunohistochemistry andimmuno-fluorescencealsorevealednosignificantinflammatoryreactionfromeitherofthemicrofilms,whichconfirmed thatbothmicrofilmsarebiocompatible.Thedurationofthedrugdeliverycanbetailoredbyselectingthematerials,which havedifferentdegradationkinetics,tosuitthedesiredclinicaltherapeuticapplication. Citation: Peng Y, Ang M, Foo S, Lee WS, Ma Z, et al. (2011) Biocompatibility and Biodegradat