CDKN1C (p57KIP2) Is a Direct Target of EZH2 and Suppressed by Multiple Epigenetic Mechanisms in Breast Cancer Cells 英文参考文献.docVIP

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CDKN1C (p57KIP2) Is a Direct Target of EZH2 and Suppressed by Multiple Epigenetic Mechanisms in Breast Cancer Cells 英文参考文献.doc

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CDKN1C (p57KIP2) Is a Direct Target of EZH2 and Suppressed by Multiple Epigenetic Mechanisms in Breast Cancer Cells 英文参考文献

CDKN1C(p57KIP2)IsaDirectTargetofEZH2and SuppressedbyMultipleEpigeneticMechanismsinBreast CancerCells XiaojingYang1,2,R.K.MurthyKaruturi3,FengSun1,4,MeiyeeAau1,KunYu5,RongguangShao2,LanceD. Miller1,PatrickBoonOoiTan5,6,QiangYu1* 1CancerBiologyandPharmacology,GenomeInstituteofSingapore,A*STAR(AgencyforScience,TechnologyandResearch),Biopolis,Singapore,2InstituteofMedicinal Biotechnology, Chinese Academy of Medical Sciences, Beijing, China, 3Information and Mathematical Science, Genome Institute of Singapore, A*STAR (Agency for Science, Technology and Research), Biopolis, Singapore, 4Department of Pharmacy, National University of Singapore, Singapore, Singapore, 5Duke-NUS Graduate Medical School, Singapore, Singapore, 6Cell and Medical Biology, Genome Institute of Singapore, A*STAR (Agency for Science, Technology and Research), Biopolis, Singapore Abstract CDKN1C(encodingtumorsuppressorp57KIP2)isacyclin-dependentkinase(CDK)inhibitorwhosefamilymembersareoften transcriptionally downregulatedin humancancer via promoter DNAmethylation.Inthis study, weshow that CDKN1Cis repressedinbreastcancercellsmainlythroughhistonemodifications.Inparticular,weshowthatCDKN1Cistargetedby histonemethyltransferaseEZH2-mediatedhistoneH3lysine27trimethylation(H3K27me3),andcanbestronglyactivatedby inhibitionofEZH2insynergywithhistonedeacetylaseinhibitor.ConsistentwiththeoverexpressionofEZH2inavarietyof humancancersincludingbreastcancer,CDKN1Cinthesecancersisdownregulated,andbreasttumorsexpressinglowlevels ofCDKN1Careassociatedwithapoorprognosis.WefurthershowthatassessingbothEZH2andCDKN1Cexpressionlevels asameasurementofEZH2pathwayactivityprovidesamorepredictivepowerofdiseaseoutcomethanthatachievedwith EZH2orCDKN1Calone.Takentogether,ourstudyrevealsanovelepigeneticmechanismgoverningCDKN1Crepressionin breast cancer. Importantly, as a newly identified EZH2 target with prognostic value, it has implications in patient stratificationforcancertherapeutictargetingEZH2-mediatedgenerepression. Citation: