Cellular Model of Warburg Effect Identifies Tumor Promoting Function of UCP2 in Breast Cancer and Its Suppression by Genipin 英文参考文献.docVIP

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Cellular Model of Warburg Effect Identifies Tumor Promoting Function of UCP2 in Breast Cancer and Its Suppression by Genipin 英文参考文献.doc

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Cellular Model of Warburg Effect Identifies Tumor Promoting Function of UCP2 in Breast Cancer and Its Suppression by Genipin 英文参考文献

CellularModelofWarburgEffectIdentifiesTumor PromotingFunctionofUCP2inBreastCancerandIts SuppressionbyGenipin VanniarajanAyyasamy1.,KjerstinM.Owens1.,MohamedMokhtarDesouki2,PingLiang3 ,Andrei Bakin1,KumarasamyThangaraj4,DonaldJ.Buchsbaum5,AlbertF.LoBuglio6,KeshavK.Singh1,7* 1Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York, United States of America, 2Department of Pathology and Laboratory Medicine, MedicalUniversityofSouthCarolina,Charleston,SouthCarolina,UnitedStatesofAmerica,3DepartmentofBiologicalSciences,BrockUniversity,St.Catharines,Ontario, Canada,4CentreforCellularandMolecularBiology,Hyderabad,India,5DepartmentofRadiationOncology,UniversityofAlabamaatBirmingham,Birmingham,Alabama, UnitedStatesofAmerica,6UniversityofAlabamaatBirminghamComprehensiveCancerCenter,UniversityofAlabamaatBirmingham,Birmingham,Alabama,United States of America, 7Departments of Genetics, Pathology, Environmental Health, Center for Free Radical Biology, Center for Aging and University of Alabama at BirminghamComprehensiveCancerCenter,UniversityofAlabamaatBirmingham,Birmingham,Alabama,UnitedStatesofAmerica Abstract TheWarburgEffectischaracterizedbyanirreversibleinjurytomitochondrialoxidativephosphorylation(OXPHOS)andan increasedrateofaerobicglycolysis.Inthisstudy,weutilizedabreastepithelialcelllinelackingmitochondrialDNA(rho0) thatexhibitstheWarburgEffectassociatedwithbreastcancer.WedevelopedaMitoExpressarrayforrapidanalysisofall knownnucleargenesencodingthemitochondrialproteome.Thegene-expressionpatternwascomparedamonganormal breastepithelialcellline,itsrho0derivative,breastcancercelllinesandprimarybreasttumors.Amongseveralgenes,our studyrevealedthatover-expressionofmitochondrialuncouplingproteinUCP2inrho0breastepithelialcellsreflectsgene expressionchangesinbreastcancercelllinesandinprimarybreasttumors.Furthermore,over-expressionofUCP2wasalso foundinleukemia,ovarian,bladder,esophagus,testicular,colorectal,kidney,pancreatic,lungandprostatetumors.Ectopic exp