Differential Expression of NK Receptors CD94 and NKG2A by T Cells in Rheumatoid Arthritis Patients in Remission Compared to Active Disease 英文参考文献.docVIP

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Differential Expression of NK Receptors CD94 and NKG2A by T Cells in Rheumatoid Arthritis Patients in Remission Compared to Active Disease 英文参考文献.doc

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Differential Expression of NK Receptors CD94 and NKG2A by T Cells in Rheumatoid Arthritis Patients in Remission Compared to Active Disease 英文参考文献

DifferentialExpressionofNKReceptorsCD94andNKG2A byTCellsinRheumatoidArthritisPatientsinRemission ComparedtoActiveDisease CearaE.Walsh1*,ElizabethJ.Ryan2,ClionaO’Farrelly2,LucyGolden-Mason2,OliverFitzGerald1, DouglasJ.Veale1,BarryBresnihan1,UrsulaFearon1 1Translation Rheumatology Research Group, Dublin Academic Medical Centre, St. Vincent’s University Hospital, Elm Park, Dublin, Ireland, 2School of Biochemistry Immunology,TrinityCollege,Dublin,Ireland Abstract Objective:TNFinhibitors(TNFi)haverevolutionisedthetreatmentofrheumatoidarthritis(RA).Naturalkiller(NK)cellsand Natural Killer Cell Receptor+ T (NKT) cells comprise important effector lymphocytes whose activity is tightly regulated through surface NK receptors (NKRs). Dysregulation of NKRs in patients with autoimmune diseases has been shown, however little is known regarding NKRs expression in patients with TNFi-induced remission and in those who maintain remissionvsdiseaseflarefollowingTNFiwithdrawal. Methods:PatientswithRAwererecruitedforthisstudy,(i)RApatientsinclinicalremissionfollowingaminimumofoneyear ofTNFitherapy(n=215);(2)ActiveRApatients,notcurrentlyoreverreceivingTNFi(n=18);andhealthycontrolvolunteers (n=15).Patientsinremissionweredividedintotwogroups:thosewhoweremaintainedonTNFiandthosewhowithdrew fromTNFiandmaintainedonDMARDS.Allpatientsunderwentfullclinicalassessment.Peripheralbloodmononuclearcells were isolated and NKR (CD94, NKG2A, CD161, CD69, CD57, CD158a, CD158b) expression on T-(CD3+CD562), NK- (CD32CD56 )andNKT-(CD3+CD56 )cellswasdeterminedbyflowcytometry. + + Results:FollowingTNFiwithdrawal,percentagesandnumbersofcirculatingTcells,NKcellsorNKTcellpopulationswere unchangedinpatientsinremissionversusactiveRAorHCs.ExpressionoftheNKRsCD161,CD57,CD94andNKG2Awas + + significantlyincreasedonCD3 CD56-TcellsfrompatientsinremissioncomparedtoactiveRA(p,0.05).CD3 CD56-Tcell expressionofCD94andNKG2Awassignificantlyincreasedinpatientswhoremainedinremissioncomparedwithpatients + whosediseaseflar