Differential Expression of Programmed Cell Death on the Follicular Development in Normal and Miniature Pig Ovary 英文参考文献.docVIP

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Differential Expression of Programmed Cell Death on the Follicular Development in Normal and Miniature Pig Ovary 英文参考文献.doc

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Differential Expression of Programmed Cell Death on the Follicular Development in Normal and Miniature Pig Ovary 英文参考文献

DifferentialExpressionofProgrammedCellDeathonthe FollicularDevelopmentinNormalandMiniaturePig Ovary SangHwanKim2,KwanSikMin3,NamHyungKim4,JongTaekYoon1* 1Department of Animal Life Science, Hankyong National University, Ansung, Gyeonggi-do, Korea, 2Institute of Genetic Engineering, Hankyong National University, Ansung,Gyeonggi-do,Korea,3GraduateSchoolofBioandInformationTechnology,HankyongNationalUniversity,Ansung,Gyeonggi-do,Korea,4DepartmentofAnimal Sciences,ChungbukNationalUniversity,Cheongju,Chungbuk,Korea Abstract Follicles are important in oocyte maturation. Successful estrous cycle requires remodeling of follicular cells, and proper executionofprogrammedcelldeathiscrucialfornormalfolliculardevelopment.Theobjectivesofthepresentstudywere tounderstandprogrammedcelldeathduringfollicledevelopment,toanalyzethedifferentialfollicledevelopmentpatterns, and to assess the patterns of apoptosis and autophagy expression during follicle development in normal and miniature pigs. Through the analysis of differential patterns of programmed cell death during follicular development in porcine, MAP1LC3A,Bandotherautophagy-associatedgenes(ATG5,mTOR,Beclin-1)werefoundtoincreaseinnormalpigs,whileit decreased in miniature pigs. However, for the apoptosis-associated genes, progression of genes during follicular developmentincreasedinminiaturepigs,whileitdecreasedinnormalpigs.Thus,resultsshowthatnormalandminiature pigs showed distinct patterns of follicular remodeling manifesting that programmed cell death largely depends on the typesofpathwayduringfolliculardevelopment(TypeIIorautophagyfornormalpigsandTypeIorapoptosisforminiature pigs). Citation:KimSH,MinKS,KimNH,YoonJT(2012)DifferentialExpressionofProgrammedCellDeathontheFollicularDevelopmentinNormalandMiniaturePig Ovary.PLoSONE7(10):e46194.doi:10.1371/journal.pone.0046194 Editor:BinHe,BaylorCollegeofMedicine,UnitedStatesofAmerica ReceivedJune12,2012;AcceptedAugust28,2012;PublishedOctober8,2012 Copyright:?2012Kimetal.Thisisanopen-ac