Distinct Cardiac Transcriptional Profiles Defining Pregnancy and Exercise 英文参考文献.docVIP

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Distinct Cardiac Transcriptional Profiles Defining Pregnancy and Exercise 英文参考文献.doc

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Distinct Cardiac Transcriptional Profiles Defining Pregnancy and Exercise 英文参考文献

DistinctCardiacTranscriptionalProfilesDefining PregnancyandExercise EunheeChung1,2.,JosephHeimiller1.,LeslieA.Leinwand1,2 * 1DepartmentofMolecular,Cellular,andDevelopmentalBiology,UniversityofColoradoatBoulder,Boulder,Colorado,UnitedStatesofAmerica,2BiofrontiersInstitute, UniversityofColoradoatBoulder,Boulder,Colorado,UnitedStatesofAmerica Abstract Background: Although the hypertrophic responses of the heart to pregnancy and exercise are both considered to be physiologicalprocesses,theyoccurinquitedifferenthormonalandtemporalsettings.Inthisstudy,wehavecomparedthe global transcriptional profiles of left ventricular tissues at various time points during the progression of hypertrophy in exerciseandpregnancy. Methodology/Principal Findings: The following groups of female mice were analyzed: non-pregnant diestrus cycle sedentary control, mid-pregnant, late-pregnant, and immediate-postpartum, and animals subjected to 7 and 21 days of voluntarywheelrunning.Hierarchicalclusteringanalysisshowsthatwhilemid-pregnancyandbothexercisegroupsshare the closest relationship and similar gene ontology categories, late pregnancy and immediate post-partum are quite differentwithhighrepresentationofsecreted/extracellularmatrix-relatedgenes.Moreover,pathway-orientedontological analysisshowsthatmetabolismregulatedbycytochromeP450andchemokinepathwaysarethemostsignificantsignaling pathways regulated in late pregnancy and immediate-postpartum, respectively. Finally, increases in expression of components of the proteasome observed in both mid-pregnancy and immediate-postpartum also result in enhanced proteasomeactivity.Interestingly, thegeneexpressionprofiles didnotcorrelate withthedegreeof cardiachypertrophy observed in the animal groups, suggesting that distinct pathways are employed to achieve similar amounts of cardiac hypertrophy. Conclusions/Significance:Ourresultsdemonstratethatcardiacadaptationtothelaterstagesofpregnancyisquitedistinct from both mid-pregnancy and exercise. Furthe