Distinct Cerebrospinal Fluid Proteomes Differentiate Post-Treatment Lyme Disease from Chronic Fatigue Syndrome 英文参考文献.docVIP

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Distinct Cerebrospinal Fluid Proteomes Differentiate Post-Treatment Lyme Disease from Chronic Fatigue Syndrome 英文参考文献.doc

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Distinct Cerebrospinal Fluid Proteomes Differentiate Post-Treatment Lyme Disease from Chronic Fatigue Syndrome 英文参考文献

DistinctCerebrospinalFluidProteomesDifferentiate Post-TreatmentLymeDiseasefromChronicFatigue Syndrome StevenE.Schutzer1*.,ThomasE.Angel4.,TaoLiu4.,AthenaA.Schepmoes4,ThereseR.Clauss4, JoshuaN.Adkins4,DavidG.Camp II4,BartK.Holland3,JonasBergquist5,PatriciaK.Coyle6,RichardD. Smith4,BrianA.Fallon7,BenjaminH.Natelson2,8 1DepartmentofMedicine,UniversityofMedicineandDentistryofNewJersey-NewJerseyMedicalSchool,Newark,NewJersey,UnitedStatesofAmerica,2Departmentof Neurology,UniversityofMedicineandDentistryofNewJersey-NewJerseyMedicalSchool,Newark,NewJersey,UnitedStatesofAmerica,3DivisionofBiostatisticsand Epidemiology, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, New Jersey, United States of America, 4Biological Sciences Division,PacificNorthwestNationalLaboratory,Richland,Washington,UnitedStatesofAmerica,5DepartmentofPhysicalandAnalyticalChemistry,UppsalaUniversity, Uppsala,Sweden,6DepartmentofNeurology,StateUniversityofNewYork-StonyBrook,StonyBrook,NewYork,UnitedStatesofAmerica,7DepartmentofPsychiatry, ColumbiaUniversityMedicalCenter,NewYork,NewYork,UnitedStatesofAmerica,8DepartmentofPainMedicineandPalliativeCareandBethIsraelMedicalCenter, AlbertEinsteinSchoolofMedicine,Bronx,NewYork,UnitedStatesofAmerica Abstract Background: Neurologic Post Treatment Lyme disease (nPTLS) and Chronic Fatigue (CFS) are syndromes of unknown etiology.Theysharefeaturesoffatigueandcognitivedysfunction,makingitdifficulttodifferentiatethem.Unresolvedis whethernPTLSisasubsetofCFS. MethodsandPrincipalFindings:Pooledcerebrospinalfluid(CSF)samplesfromnPTLSpatients,CFSpatients,andhealthy volunteers were comprehensively analyzed using high-resolution mass spectrometry (MS), coupled with immunoaffinity depletionmethodstoreduceprotein-maskingbyabundantproteins.IndividualpatientandhealthycontrolCSFsamples wereanalyzeddirectlyemployingaMS-basedlabel-freequantitativeproteomicsapproach.Wefoundthatbothgroups,and individuals within the groups, could be distinguished