Dkk4 and Eda Regulate Distinctive Developmental Mechanisms for Subtypes of Mouse Hair 英文参考文献.docVIP

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Dkk4 and Eda Regulate Distinctive Developmental Mechanisms for Subtypes of Mouse Hair 英文参考文献.doc

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Dkk4 and Eda Regulate Distinctive Developmental Mechanisms for Subtypes of Mouse Hair 英文参考文献

Dkk4andEdaRegulateDistinctiveDevelopmental MechanismsforSubtypesofMouseHair Chang-YiCui,MakotoKunisada,YulanPiao,VictoriaChildress,MinoruS.H.Ko,DavidSchlessinger* LaboratoryofGenetics,NationalInstituteonAging,NationalInstitutesofHealth,Baltimore,Maryland,UnitedStatesofAmerica Abstract The mouse hair coat comprises protective ‘‘primary’’ and thermo-regulatory ‘‘secondary’’ hairs. Primary hair formation is ectodysplasin(Eda)dependent,butithasbeenpuzzlingthatTabby(Eda-/y)micestillmakesecondaryhair.Wereportthat Dickkopf4(Dkk4),aWntantagonist,affectsanauxiliarypathwayforEda-independentdevelopmentofsecondaryhair.A Dkk4transgeneinwild-typemicehadnoeffectonprimaryhair,butsecondaryhairswereseverelymalformed.Dkk4action on secondary hair was further demonstrated when the transgene was introduced into Tabby mice: the usual secondary follicleinductionwascompletelyblocked.TheDkk4-regulatedsecondaryhairpathway,liketheEda-dependentprimaryhair pathway,isfurthermediatedbyselectiveactivationofShh.Theresultsthusrevealtwocomplexmolecularpathwaysthat distinctlyregulatesubtype-basedmorphogenesisofhairfollicles,andprovidearesolutionforthelongstandingpuzzleof hairformationinTabbymicelackingEda. Citation:CuiC-Y,KunisadaM,PiaoY,ChildressV,KoMSH,etal.(2010)Dkk4andEdaRegulateDistinctiveDevelopmentalMechanismsforSubtypesofMouse Hair.PLoSONE5(4):e10009.doi:10.1371/journal.pone.0010009 Editor:GregoryS.Barsh,StanfordUniversitySchoolofMedicine,UnitedStatesofAmerica ReceivedDecember2,2009;AcceptedMarch8,2010;PublishedApril1,2010 Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCommonsPublicDomaindeclarationwhichstipulatesthat,onceplacedinthepublic domain,thisworkmaybefreelyreproduced,distributed,transmitted,modified,builtupon,orotherwiseusedbyanyoneforanylawfulpurpose. Funding: ThisworkwassupportedbytheIRPoftheNIH/NationalInstituteonAging.Thefundershadnoroleinstudy design,datacollectionandanalysis, decisiontopublish,orpreparationofthemanuscript. CompetingInterests:Theauthorsha