Episodic Memory in Detoxified Alcoholics Contribution of Grey Matter Microstructure Alteration 英文参考文献.docVIP

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Episodic Memory in Detoxified Alcoholics Contribution of Grey Matter Microstructure Alteration 英文参考文献.doc

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Episodic Memory in Detoxified Alcoholics Contribution of Grey Matter Microstructure Alteration 英文参考文献

EpisodicMemoryinDetoxifiedAlcoholics:Contribution ofGreyMatterMicrostructureAlteration SandraChanraud1,2,3,4,5*,ClaireLeroy1,2,3,CatherineMartelli6,NikoletaKostogianni6,7,Franc?oise Delain6,Henri-JeanAubin7,MichelReynaud6,Jean-LucMartinot1,2,3 1Inserm,U797ResearchUnit‘‘NeuroimagingPsychiatry’’,IFR49,Orsay,France,2CEA,‘‘NeuroimagingPsychiatry’’U797Unit,HospitalDepartmentFre′de′ricJoliot Neurospin,I2BM,Orsay,France,3UnivParisSud,UMRU797,OrsayandUnivParisDescartes,UMRU797,Paris,France,4DepartmentofPsychiatryandBehavioralSciences, StanfordUniversitySchoolofMedicine,Stanford,California,UnitedStatesofAmerica,5NeuroscienceProgram,SRIInternational,MenloPark,California,UnitedStatesof America,6APHP,Departmentofpsychiatryandaddictology,PaulBrousseHospital,Villejuif,France,7APHP,AddictionTreatmentCenter,EmileRouxHospital,Limeil- Brevannes,France Abstract Even though uncomplicated alcoholics may likely have episodic memory deficits, discrepancies exist regarding to the integrityofbrainregionsthatunderliethisfunctioninhealthysubjects.Possiblerelationshipsbetweenepisodicmemory and1)brainmicrostructureassessedbymagneticresonancediffusiontensorimaging(DTI),2)brainvolumesassessedby voxel-basedmorphometry(VBM)wereinvestigatedinuncomplicated,detoxifiedalcoholics. Diffusionandmorphometric analyseswereperformedin24alcoholdependentmenwithoutneurologicalorsomaticcomplicationsandin24healthy men. The mean apparent coefficient of diffusion (ADC) and grey matter volumes were measured in the whole brain. EpisodicmemoryperformancewasassessedusingaFrenchversionoftheFreeandCuedSelectiveRemindingTest(FCSRT). Correlation analyses between verbal episodic memory, brain microstructure, and brain volumes were carried out using SPM2 software. In those with alcohol dependence, higher ADC was detected mainly in frontal, temporal and parahippocampalregions,andinthecerebellum.Inalcoholics,regionswithhigherADCtypicallyalsohadlowergreymatter volume.Lowverbalepisodicmemoryperformanceinalcoholismwasassoci