年产15吨的替米沙坦原料药车间工艺设计大学毕业论文 毕业设计论文 .docVIP

摘要 Abstract The design of 15 tons of telmisartan workshop process design.In this design, I use is 4 - methyl - 2 - propyl benzene and 1 h - imidazole - 6 - formic acid and N - methyl o-phenylendiamine as raw material after ring condensation reaction, and - bromine biphenyl, 4 - 2 - methyl formate substitution reaction, finally after hydrolysis reaction of alcohol telmisartan process.The main steps of the design for the cyclic condensation, substitution reaction, hydrolysis reaction, and the yield was 71.2%, 82% and 86% in turn.According to the specification requirements, set for 301 days as a benchmark, telmisartan output of 15 tons. In this design, we first through the literature data of telmisartan and its raw materials of various physical parameters in the query of the intermediate products and the records, then, to understand its clinical use, adverse reactions, and all kinds of pharmacology and toxicology.Then according to the design drawing the process flow diagram.Second, we in the reaction kettle has carried on the material balance, and lists the reaction kettle in and out of the material balance.On the basis of above, complete the material balance and equipment type selection, and draw a process flow chart with control points.Then according to the code for the pharmaceutical production management, etc., and according to the design of the actual situation, has carried on the detailed labor personnel arrangement.Finally, according to the nature of the waste in the production and discharge, formulate measures for reasonable utilization and three wastes. 【key word】 Annual output of 15 tons of telmisartan;Material balance;Heat balance 摘要 I Abstract II 第一章 产品概述 1 1.1 基本信息、化学结构、性状与规格 1 1.1.1 产品名称 1 1.1.2 化学结构、分子式、分子量 1 1.1.3 性状与规格 1 1.2 产品药理毒理 2 1.3 适应症与不良反应 2 1.4 用法用量 3 1.5 禁忌 3 第二章 生产工艺 5 2.1 生产工艺路线 5 2.2 生产工艺操作过程 5 2.2.1 环缩合反应式及操作步骤 5 2.2.2 取代反应式及操作步骤 6 2.2.3 水解反应式及操作步骤 6 2.2.4 包装 7 2.3 工艺流程框图 7 2.4“三废”处理及综合利用 7 2.4.1 废气 7 2.4.