Fetal Growth versus Birthweight The Role of Placenta versus Other Determinants 英文参考文献.docVIP

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Fetal Growth versus Birthweight The Role of Placenta versus Other Determinants 英文参考文献.doc

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Fetal Growth versus Birthweight The Role of Placenta versus Other Determinants 英文参考文献

FetalGrowthversusBirthweight:TheRoleofPlacenta versusOtherDeterminants MarieCeciliePaascheRoland1*,CamillaM.Friis1,NannaVoldner1,KristinGodang2,JensBollerslev2,3, GuttormHaugen1,3,ToreHenriksen1,3 1DepartmentofObstetrics,OsloUniversityHospital,Oslo,Norway,2DepartmentofSpecializedEndocrinology,OsloUniversityHospital,Oslo,Norway,3Universityof Oslo,Oslo,Norway Abstract Introduction: Birthweight is used as an indicator of intrauterine growth, and determinants of birthweight are widely studied. Less is known about determinants of deviating patterns of growth in utero. We aimed to study the effects of maternalcharacteristicsonbothbirthweightandfetalgrowthinthirdtrimesterandintroduceplacentalweightasapossible determinantofbothbirthweightandfetalgrowthinthirdtrimester. Methods:TheSTORKstudyisaprospectivecohortstudyincluding1031healthypregnantwomenofScandinavianheritage withsingletonpregnancies.Maternaldeterminants(age,parity,bodymassindex(BMI),gestationalweightgainandfasting plasma glucose) of birthweight and fetal growth estimated by biometric ultrasound measures were explored by linear regression models. Two models were fitted, one with only maternal characteristics and one which included placental weight. Results: Placental weight was a significant determinant of birthweight. Parity, BMI, weight gain and fasting glucose remained significantwhen adjusted for placental weight.Introducing placentalweight as acovariate reduced theeffect estimate of the other variables in the model by 62% for BMI, 40% for weight gain, 33% for glucose and 22% for parity. Determinantsoffetalgrowthwereparity,BMIandweightgain,butnotfastingglucose.Placentalweightwassignificantas anindependentvariable.Parity,BMIandweightgainremainedsignificantwhenadjustedforplacentalweight.Introducing placentalweightreducedtheeffectofBMIonfetalgrowthby23%,weightgainby14%andparityby17%. Conclusion:Inconclusion,wefindthatplacentalweightisanimportantdeterminantofbothbirthweightandfetalgrowth. Ourfindingsindicatethat