Gaining Greater Insight into HCV Emergence in HIV-Infected Men Who Have Sex with Men The HEPAIG Study 英文参考文献.docVIP

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Gaining Greater Insight into HCV Emergence in HIV-Infected Men Who Have Sex with Men The HEPAIG Study 英文参考文献.doc

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Gaining Greater Insight into HCV Emergence in HIV-Infected Men Who Have Sex with Men The HEPAIG Study 英文参考文献

GainingGreaterInsightintoHCVEmergenceinHIV- InfectedMenWhoHaveSexwithMen:TheHEPAIGStudy ChristineLarsen1*,Marie-LaureChaix2,YannLeStrat1,AnnieVelter1,AnneGervais3,IsabelleAupe′rin4, LaurentAlric5,XavierDuval6,PatrickMiailhes7,CorinnePioche1,StanislasPol8,LionelPiroth9 ,Elisabeth Delarocque-Astagneau1,10,forthesteeringcommitteeoftheHEPAIGstudy 1National Institute for Public Health Surveillance (InVS), Saint-Maurice, France, 2University Paris Descartes, EA 3620, Virology Department, APHP, Paris, France, 3Hepatology Department, Bichat University Hospital, Paris, France, 4Internal Medicine Department, Community Hospital, Montreuil, France, 5Digestive Department, ToulouseIIIUniversity,Toulouse,France,6InfectiousDiseasesDepartment,BichatUniversityHospital,Paris,France,7InfectiousDiseasesDepartment,HospicesCivilesde Lyon,Croix-RousseHospital,Lyon,France,8UniversityParisDescartes,InsermU1016,LiverUnit,AssistancePublique-Ho?pitauxdeParis,CochinHospital,Paris,France, 9InfectiousDiseasesDepartment,UniversityHospital,Dijon,France,10Unite′ d’E′pide′miologie desMaladiesE′mergentes,InstitutPasteur,Paris,France Abstract Objectives: The HEPAIG study was conducted to better understand Hepatitis C virus (HCV) transmission among human immuno-deficiency(HIV)-infectedmenwhohavesexwithmen(MSM)andassessincidenceofHCVinfectionamongthis populationinFrance. MethodsandResults:AcuteHCVinfectiondefinedbyanti-HCVorHCVribonucleicacid(RNA)positivitywithinoneyearof documentedanti-HCVnegativitywasnotifiedamongHIV-infectedMSMfollowedupinHIV/AIDSclinicsfromanationwide samplingframe.HIVandHCVinfectioncharacteristics,HCVpotentialexposuresandsexualbehaviourwerecollectedbythe physiciansandviaself-administeredquestionnaires.PhylogeneticanalysisoftheHCV-NS5Bregionwasconducted. HCV incidencewas48/10000[95%ConfidenceInterval(CI):43–54]and36/10000[95%CI:30–42]in2006and2007,respectively. Amongthe80menenrolled(medianage:40years),55%wereHIV-diagnosedbefore2000,56%hadatleastonesexually transmittedinfectionint