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Generalized Seizure in a Mauritian Woman Taking Bupropion 英文参考文献
o
Openaccess,freelyavailableonline PL S
MEDICINE
CaseReport
GeneralizedSeizureinaMauritianWoman
TakingBupropion
Marie France Lan Cheong Wah1*,Lan Sem Hing Lan Cheong Wah2
Casereportfrom1FacultyofScience,UniversityofMauritius,Reduit,Mauritius, 2Port-Louis,Mauritius
CompetingInterests:Theauthors
havedeclaredthatnocompeting
interestsexist.
PRESENTATIONofCASE
should be discontinued if abstinence is not
achievedby7wk.
A
The ef?cacy of bupropion as an aid to
smoking cessation has been shown in
randomized, double-blind, placebo-con-
trolled trials [1,2]. But there have also been
reports of death, seizure, serum sickness,
generalized acute urticaria, myocardial in-
farction, and psychosis in people taking the
drug[3,4,5,6,7].Ourreportisofawomanwho
hadageneralizedseizureonthesixthdayof
treatmentwithbupropion;shehadnoother
riskfactorsforseizures.
24-y-old woman was admitted to
the emergency department having
hadageneralizedseizure(acuteloss
AuthorContributions:Both
authorscontributedequallyto
preparingthecasereport.
of consciousness, convulsive movements of
herarmsandlegs,andconfusiononregain-
ingconsciousness).Shewasonthesixthday
of treatment with 300 mg daily of slow-
release bupropion (Zyban SR) as an aid to
smoking cessation. She had a past medical
history of tonsillectomy and hay fever, for
which she was taking budesonide nasal
drops (two drops daily, each drop 200
mcg).Shewasonnoothermedication.There
wasnohistoryofheadtrauma,liverdisease,
or alcohol withdrawal. Clinical examination,
includingneurologicalexamination,wasnor-
mal. The patient’s weight was 48 kg. Her
blood pressure was 130/80 mm Hg. Electro-
cardiogram showed a sinus tachycardia at
102 beats per minute. Radiography of the
skull and a computed tomography scan of
thebrainwithoutcontrastwerebothnormal.
The patient’s blood glucose, urea, electro-
lytes,andliverfunctiontestswereallnormal.
Herserumcalciumwas2.01mmol/l(normal
range, 2.0–2.6 mmol/l) and her hemoglobin
was116g/l(normalrange,120–14
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