Generalization of Stochastic Visuomotor Rotations 英文参考文献.docVIP

GeneralizationofStochasticVisuomotorRotations HugoL.Fernandes1,2,3*,IanH.Stevenson4,KonradP.Kording1,5,6 1DepartmentofPhysicalMedicineandRehabilitation,NorthwesternUniversityandRehabilitationInstituteofChicago,Chicago,Illinois,UnitedStatesofAmerica,2PDBC, InstitutoGulbenkiandeCie?ncia,Oeiras,Portugal, 3InstitutodeTecnologiaQu?′micaeBiolo′gica,UniversidadeNova deLisboa,Oeiras,Portugal,4RedwoodCenterfor TheoreticalNeuroscience,UniversityofCalifornia,Berkeley,California,UnitedStatesofAmerica,5DepartmentofPhysiology,NorthwesternUniversity,Chicago,Illinois, UnitedStatesofAmerica,6DepartmentofAppliedMathematics,NorthwesternUniversity,Chicago,Illinois,UnitedStatesofAmerica Abstract Generalization studies examine the influence of perturbations imposed on one movement onto other movements. The strength of generalization is traditionally interpreted as a reflection of the similarity of the underlying neural representations. Uncertainty fundamentally affects both sensory integration and learning and is at the heart of many theories of neural representation. However, little is known about how uncertainty, resulting from variability in the environment, affects generalization curves. Here we extend standard movement generalization experiments to ask how uncertaintyaffectsthegeneralizationofvisuomotorrotations.Wefindthatalthoughuncertaintyaffectshowfastsubjects learn,theperturbationgeneralizesindependentlyofuncertainty. Citation: Fernandes HL, Stevenson IH, Kording KP (2012) Generalization of Stochastic Visuomotor Rotations. PLoS ONE 7(8): e43016. doi:10.1371/ journal.pone.0043016 Editor:DanielOsorio,UniversityofSussex,UnitedKingdom ReceivedApril30,2012;AcceptedJuly16,2012;PublishedAugust14,2012 Copyright: ?2012 Fernandes et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding: HLF was suppor