Gender Differences in a Drosophila Transcriptomic Model of Chronic Pentylenetetrazole Induced Behavioral Deficit 英文参考文献.docVIP

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Gender Differences in a Drosophila Transcriptomic Model of Chronic Pentylenetetrazole Induced Behavioral Deficit 英文参考文献.doc

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Gender Differences in a Drosophila Transcriptomic Model of Chronic Pentylenetetrazole Induced Behavioral Deficit 英文参考文献

GenderDifferencesinaDrosophilaTranscriptomic ModelofChronicPentylenetetrazoleInducedBehavioral Deficit AbhaySharma*,FarhanMohammad¤,PriyankaSingh InstituteofGenomicsandIntegrativeBiology,CouncilofScientificandIndustrialResearch,DelhiUniversityCampus,Delhi,India Abstract AmaleDrosophilamodeloflocomotordeficitinducedbychronicpentylenetetrazole(PTZ),aproconvulsantusedtomodel epileptogenesis in rodents, has recently been described. Antiepileptic drugs (AEDs) ameliorate development of this behavioral abnormality. Time-series of microarray profiling of heads of male flies treated with PTZ has shown epileptogenesis-like transcriptomic perturbation in the fly model. Gender differences are known to exist in neurological andpsychiatricconditionsincludingepileptogenesis.WedescribeheretheeffectsofchronicPTZinDrosophilafemales,and compare the results with the male model. As in males, chronic PTZ was found to cause a decreased climbing speed in females. In males, overrepresentation of Wnt, MAPK, TGF-beta, JAK-STAT, Cell communication, and Dorso-Ventral axis formationpathwaysindownregulatedgeneswaspreviouslydescribed.Ofthese,femalegenesshowedenrichmentonlyfor Dorso-Ventralaxisformation.Surprisingly,theribosomalpathwaywasuniquelyoverrepresentedingenesdownregulatedin females.GenderdifferencesthusexistintheDrosophilamodel.Genderneutral,thedevelopmentalpathwayDorso-Ventral axisformationmaybeconsideredasthecandidatecausalpathwayinchronicpentylenetetrazoleinducedbehavioraldeficit. Priorevidenceofdevelopmentalmechanismsinepileptogenesismaysupportpotentialusefulnessoftheflymodel.Given this, gender specific pathways identified here may provide a lead for further understanding brain dimorphism in neuropsychiatricdisorders. Citation:SharmaA,MohammadF,SinghP(2009)GenderDifferencesinaDrosophilaTranscriptomicModelofChronicPentylenetetrazoleInducedBehavioral Deficit.PLoSONE4(12):e8136.doi:10.1371/journal.pone.0008136 Editor:Jo¨rgHoheisel,DeutschesKrebsforschungszentrum,Germany ReceivedJuly27