Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition 英文参考文献.docVIP

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Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition 英文参考文献.doc

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Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition 英文参考文献

GenerationofBreastCancerStemCellsthrough Epithelial-MesenchymalTransition Anne-PierreMorel1,MarjoryLie`vre1,Cle′menceThomas1,2,GeorgeHinkal1,2,Ste′phaneAnsieau1,2 ,Alain Puisieux1,2,3 * 1CentreLe′on Be′rard,Lyon,France,2Inserm,U590,Lyon,France,3Universite′ deLyon,Lyon1,ISPB,Lyon,France Abstract Recently,twonovelconceptshaveemergedincancerbiology:theroleofso-called‘‘cancerstemcells’’intumorinitiation, andtheinvolvementofanepithelial-mesenchymaltransition(EMT)inthemetastaticdisseminationofepithelialcancercells. Usingamammarytumorprogressionmodel,weshowthatcellspossessingbothstemandtumorigeniccharacteristicsof ‘‘cancerstemcells’’canbederivedfromhumanmammaryepithelialcellsfollowingtheactivationoftheRas-MAPKpathway. TheacquisitionofthesestemandtumorigeniccharactersisdrivenbyEMTinduction. Citation:MorelA-P,Lie`vreM,ThomasC,HinkalG,AnsieauS,etal.(2008)GenerationofBreastCancerStemCellsthroughEpithelial-MesenchymalTransition.PLoS ONE3(8):e2888.doi:10.1371/journal.pone.0002888 Editor:JuhaKlefstrom,UniversityofHelsinki,Finland ReceivedMarch14,2008;AcceptedJuly14,2008;PublishedAugust6,2008 Copyright: ? 2008 Morel et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:ThisworkwasgrantedbytheInstitutNationalduCancer,theLiguecontreleCancerandtheBreastCancerResearchFoundation. CompetingInterests:Theauthorshavedeclaredthatnocompetinginterestsexist. *E-mail:puisieux@lyon.fnclcc.fr Introduction phenotypeofthesecellswasfurtherrefinedbytheDaidonegroup, whowereabletogrowmammospheresfromsingle-cellsuspensions obtained from the dissociation of primary breast tumors [3]. Mammospheres are non-adherent spherical cell clusters obtained inselectivecultureconditions,thathavebeenshowntobeenriched inmammarystem/progenitorcells[26].Thevastmajorityofcellsin culturewereCD44+CD242/low,and10to20%oftheseretainedthe abi