Genes Are Often Sheltered from the Global Histone Hyperacetylation Induced by HDAC Inhibitors 英文参考文献.docVIP

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Genes Are Often Sheltered from the Global Histone Hyperacetylation Induced by HDAC Inhibitors 英文参考文献.doc

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Genes Are Often Sheltered from the Global Histone Hyperacetylation Induced by HDAC Inhibitors 英文参考文献

GenesAreOftenShelteredfromtheGlobalHistone HyperacetylationInducedbyHDACInhibitors JohnHalsall.,VibhorGupta.,LauraP.O’Neill,BryanM.Turner,KarlP.Nightingale* ChromatinandGeneExpressionGroup,InstituteofBiomedicalResearch,CollegeofMedicalandDentalSciences,UniversityofBirmingham,Birmingham,UnitedKingdom Abstract Histonedeacetylaseinhibitors(HDACi)areincreasinglyusedastherapeuticagents,butthemechanismsbywhichtheyalter cellbehaviourremainunclear.Hereweusemicroarrayexpressionanalysistoshowthatonlyasmallproportionofgenes (,9%) have altered transcript levels after treating HL60 cells with different HDACi (valproic acid, Trichostatin A, suberoylanilidehydroxamicacid).Differentgenepopulationsrespondtoeachinhibitor,withasmanygenesdown-asup- regulated.Surprisingly,HDACirarelyinducedincreasedhistoneacetylationatgenepromoters,withmostgenesexamined showingminimalchange,irrespectiveofwhethergeneswereup-ordown-regulated.Manygenesseemtobesheltered fromtheglobalhistonehyperacetyationinducedbyHDACi. Citation:HalsallJ,GuptaV,O’NeillLP,TurnerBM,NightingaleKP(2012)GenesAreOftenShelteredfromtheGlobalHistoneHyperacetylationInducedbyHDAC Inhibitors.PLoSONE7(3):e33453.doi:10.1371/journal.pone.0033453 Editor:SueCotterill,St.GeorgesUniversityofLondon,UnitedKingdom ReceivedJuly1,2011;AcceptedFebruary15,2012;PublishedMarch30,2012 Copyright: ? 2012 Halsall et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding: This work was supported by Cancer Research UK, Programme grant C1015/A9077 (Turner BM, Nightingale KP, ONeill LP). http://aboutus. /.Thefundershadnoroleinstudydesign,datacollectionandanalysis,decisiontopublish,orpreparationofthemanuscript. CompetingInterests:Theauthorshavedeclaredthatnocompetinginterestsexist. *E-mail:k.p.nightingale@bham.ac.uk .Theseauthorscontributedequallytothiswork. Introduction acetylation