Genetic Characterization of Zika Virus Strains Geographic Expansion of the Asian Lineage 英文参考文献.docVIP

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Genetic Characterization of Zika Virus Strains Geographic Expansion of the Asian Lineage 英文参考文献.doc

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Genetic Characterization of Zika Virus Strains Geographic Expansion of the Asian Lineage 英文参考文献

GeneticCharacterizationofZikaVirusStrains: GeographicExpansionoftheAsianLineage AndrewD.Haddow1*,AmyJ.Schuh1,ChadwickY.Yasuda2,MatthewR.Kasper2¤,VireakHeang2 ,Rekol Huy3,HildaGuzman1,RobertB.Tesh1,ScottC.Weaver1 1InstituteforHumanInfectionsandImmunity,CenterforTropicalDiseases,DepartmentofPathology,UniversityofTexasMedicalBranch,Galveston,Texas,UnitedStates ofAmerica,2UnitedStatesNavalMedicalResearchUnit,No.2,PhnomPenh,Cambodia,3NationalDengueControlProgram,PhnomPenh,Cambodia Abstract Background:Zikavirus(ZIKV)isamosquito-borneflavivirusdistributedthroughoutmuchofAfricaandAsia.Infectionwith thevirusmaycauseacutefebrileillnessthatclinicallyresemblesdenguefever.Arecentstudyindicatedtheexistenceof threegeographicallydistinctvirallineages;howeverthisanalysisutilizedonlyasingleviralgene.AlthoughZIKVhasbeen knowntocirculateinbothAfricaandAsiasinceatleastthe1950s,littleisknownaboutthegeneticrelationshipsbetween geographically distinct virus strains. Moreover, the geographic origin of the strains responsible for the epidemic that occurred on Yap Island, Federated States of Micronesia in 2007, and a 2010 pediatric case in Cambodia, has not been determined. Methodology/Principal Findings: To elucidate the genetic relationships of geographically distinct ZIKV strains and the originofthestrainsresponsibleforthe2007outbreakonYapIslandanda2010CambodianpediatriccaseofZIKVinfection, thenucleotidesequencesoftheopenreadingframeoffiveisolatesfromCambodia,Malaysia,Nigeria,Uganda,andSenegal collected between 1947 and 2010 were determined. Phylogenetic analyses of these and previously published ZIKV sequencesrevealedtheexistenceoftwomainviruslineages(AfricanandAsian)andthatthestrainresponsiblefortheYap epidemicandtheCambodiancasemostlikelyoriginatedinSoutheastAsia.Examinationofthenucleotideandaminoacid sequencealignmentsrevealedthelossofapotentialglycosylationsiteinsomeofthevirusstrains,whichmaycorrelatewith thepassagehistoryofthevirus. Conclusions/Significance: The basal position of t