Global Chromatin Domain Organization of the Drosophila Genome 英文参考文献.docVIP

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Global Chromatin Domain Organization of the Drosophila Genome 英文参考文献.doc

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Global Chromatin Domain Organization of the Drosophila Genome 英文参考文献

GlobalChromatinDomainOrganizationofthe DrosophilaGenome ElzodeWit1¤a,UlrichBraunschweig1,FraukeGreil1¤b,HarmenJ.Bussemaker2*,BasvanSteensel1* 1DepartmentofMolecularBiology,NetherlandsCancerInstitute,Amsterdam,TheNetherlands,2DepartmentofBiologicalSciences,ColumbiaUniversity,NewYork,New York,UnitedStatesofAmerica Abstract Ineukaryotes,neighboringgenescanbepackagedtogetherinspecificchromatinstructuresthatensuretheircoordinated expression. Examples of such multi-gene chromatin domains are well-documented, but a global view of the chromatin organizationofeukaryoticgenomesislacking.Tosystematicallyidentifymulti-genechromatindomains,weconstructeda compendium of genome-scale binding maps for a broad panel of chromatin-associated proteins in Drosophila melanogaster.Next,wecomputationallyanalyzedthiscompendiumforevidenceofmulti-genechromatindomainsusing anovelstatisticalsegmentationalgorithm.Wefindthatatleast50%ofallflygenesareorganizedintochromatindomains, which often consist of dozens of genes. The domains are characterized by various known and novel combinations of chromatin proteins. The genes in many of the domains are coregulated during development and tend to have similar biologicalfunctions.Furthermore, duringevolutionfewerchromosomalrearrangementsoccurinsidechromatindomains thanoutsidedomains.OurresultsindicatethatasubstantialportionoftheDrosophilagenomeispackagedintofunctionally coherent, multi-gene chromatin domains. This has broad mechanistic implications for gene regulation and genome evolution. Citation: de Wit E, Braunschweig U, Greil F, Bussemaker HJ, van Steensel B (2008) Global Chromatin Domain Organization of the Drosophila Genome. PLoS Genet4(3):e1000045.doi:10.1371/journal.pgen.1000045 Editor:WolfReik,TheBabrahamInstitute,UnitedKingdom ReceivedOctober24,2007;AcceptedFebruary29,2008;PublishedMarch28,2008 Copyright: ? 2008 de Wit et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permi