Genomic Restructuring in the Tasmanian Devil Facial Tumour Chromosome Painting and Gene Mapping Provide Clues to Evolution of a Transmissible Tumour 英文参考文献.docVIP

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Genomic Restructuring in the Tasmanian Devil Facial Tumour Chromosome Painting and Gene Mapping Provide Clues to Evolution of a Transmissible Tumour 英文参考文献.doc

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Genomic Restructuring in the Tasmanian Devil Facial Tumour Chromosome Painting and Gene Mapping Provide Clues to Evolution of a Transmissible Tumour 英文参考文献

GenomicRestructuringintheTasmanianDevilFacial Tumour:ChromosomePaintingandGeneMapping ProvideCluestoEvolutionofaTransmissibleTumour JanineE.Deakin1.*,HannahS.Bender1.,Anne-MareePearse2,WillemRens3,PatriciaC.M.O’Brien3, MalcolmA.Ferguson-Smith3,YuanyuanCheng4,KatrinaMorris4,RobynTaylor2,AndrewStuart5, KatherineBelov4,ChrisT.Amemiya5,ElizabethP.Murchison6,AnthonyT.Papenfuss7,8,JenniferA. MarshallGraves1 1Research School of Biology, The Australian National University, Canberra, Australia, 2Department of Primary Industries, Parks, Water, and Environment, Prospect, Australia, 3Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom, 4Faculty of Veterinary Science, University of Sydney, Sydney, Australia,5GenomeResourceCenter,BenaroyaResearchInstituteatVirginiaMason,Seattle,Washington,UnitedStatesofAmerica,6CancerGenomeProject,Wellcome TrustSangerInstitute,Cambridge,UnitedKingdom,7BioinformaticsDivision,TheWalterandElizaHallInstituteforMedicalResearch,Parkville,Australia,8Departmentof MathematicsandStatistics,UniversityofMelbourne,Melbourne,Australia Abstract Devilfacialtumourdisease(DFTD)isafatal,transmissiblemalignancythatthreatenstheworld’slargestmarsupialcarnivore, theTasmaniandevil,withextinction.Firstrecognisedin1996,DFTDhashadacatastrophiceffectonwilddevilnumbers, andintenseresearcheffortstounderstandandcontainthediseasehavesincedemonstratedthatthetumourisaclonalcell linetransmittedbyallograft.WeusedchromosomepaintingandgenemappingtodeconstructtheDFTDkaryotypeand determinethechromosomeandgenerearrangementsinvolvedincarcinogenesis.Chromosomepaintingonthreedifferent DFTD tumour strains determined the origins of marker chromosomes and provided a general overview of the rearrangementinDFTDkaryotypes.Mappingof105BACclonesbyfluorescenceinsituhybridisationprovidedafinerlevel ofresolutionofgenomerearrangementsinDFTDstrains.Ourfindingsdemonstratethatonlylimitedregionsofthegenome, mainlychromosomes 1andX,arerearranged inDFTD.Regionsrearrang