Global DNA Hypomethylation in Peripheral Blood Leukocytes as a Biomarker for Cancer Risk A Meta-Analysis 英文参考文献.docVIP

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Global DNA Hypomethylation in Peripheral Blood Leukocytes as a Biomarker for Cancer Risk A Meta-Analysis 英文参考文献.doc

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Global DNA Hypomethylation in Peripheral Blood Leukocytes as a Biomarker for Cancer Risk A Meta-Analysis 英文参考文献

GlobalDNAHypomethylationinPeripheralBlood LeukocytesasaBiomarkerforCancerRisk:AMeta- Analysis HaeDongWoo,JeongseonKim* CancerEpidemiologyBranch,NationalCancerCenter,Goyang-si,Korea Abstract Background:Goodbiomarkersforearlydetectionofcancerleadtobetterprognosis.However,harvestingtumortissueis invasiveandcannotberoutinelyperformed.GlobalDNAmethylationofperipheralbloodleukocyteDNAwasevaluatedasa biomarkerforcancerrisk. Methods:Weperformedameta-analysistoestimateoverallcancerriskaccordingtoglobalDNAhypomethylationlevels among studies with various cancer types and analytical methods used to measure DNA methylation. Studies were systemicallysearchedviaPubMedwithnolanguagelimitationuptoJuly2011.Summaryestimateswerecalculatedusinga fixedeffectsmodel. Results: The subgroup analyses by experimental methods to determine DNA methylation level were performed due to heterogeneity within the selected studies (p,0.001, I2: 80%). Heterogeneity was not found in the subgroup of %5-mC (p=0.393,I2:0%)andLINE-1usedsametargetsequence(p=0.097,I2:49%),whereasconsiderable varianceremainedin LINE-1(p,0.001,I2:80%)andbladdercancerstudies(p=0.016,I2:76%).Theseresultssuggestthatexperimentalmethods usedtoquantifyglobalDNAmethylationlevelsareimportantfactorsintheassociationstudybetweenhypomethylation levelsandcancerrisk.Overall,cancerrisksofthegroupwiththelowestDNAmethylationlevelsweresignificantlyhigher comparedtothegroupwiththehighestmethylationlevels[OR(95%CI):1.48(1.28–1.70)]. Conclusions: Global DNA hypomethylation in peripheral blood leukocytes may be a suitable biomarker for cancer risk. However, the association between global DNA methylation and cancer risk may be different based on experimental methods,andregionofDNAtargetedformeasuringglobalhypomethylationlevelsaswellasthecancertype.Therefore,it isimportanttoselectapreciseandaccuratesurrogatemarkerforglobalDNAmethylationlevelsintheassociationstudies betweenglobalDNAmethylationlevelsinperipheralleukocyteandcancerrisk. Citation: