Lack of Developmental Redundancy between Unc45 Proteins in Zebrafish Muscle Development 英文参考文献.docVIP

LackofDevelopmentalRedundancybetweenUnc45 ProteinsinZebrafishMuscleDevelopment SophieA.Comyn,DavidPilgrim* DepartmentofBiologicalSciences,UniversityofAlberta,Edmonton,Alberta,Canada Abstract Sincethemajorityofprotein-codinggenesinvertebrateshaveintra-genomichomologues,ithasbeendifficulttoeliminate the potential of functional redundancy from analyses of mutant phenotypes, whether produced by genetic lesion or transientknockdown.Furthercomplicatingtheseanalyses,notallgeneproductshaveactivitiesthatcanbeassayedinvitro, wheretheefficiencyofthevariousfamilymemberscanbecomparedagainstconstantsubstr