Lapatinib, a Dual EGFR and HER2 Tyrosine Kinase Inhibitor, Downregulates Thymidylate Synthase by Inhibiting the Nuclear Translocation of EGFR and HER2 英文参考文献.docVIP
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Lapatinib, a Dual EGFR and HER2 Tyrosine Kinase Inhibitor, Downregulates Thymidylate Synthase by Inhibiting the Nuclear Translocation of EGFR and HER2 英文参考文献
Lapatinib,aDualEGFRandHER2TyrosineKinase
Inhibitor,DownregulatesThymidylateSynthaseby
InhibitingtheNuclearTranslocationofEGFRandHER2
Hwang-PhillKim1,Young-KwangYoon1,Jin-WonKim2,Sae-WonHan2,Hyung-SeokHur1,JinahPark1,
Ju-HeeLee1,Do-YounOh1,2,Seock-AhIm1,2,Yung-JueBang1,2,Tae-YouKim1,2
*
1CancerResearchInstitute,SeoulNationalUniversityCollegeofMedicine,Seoul,Korea,2DepartmentofInternalMedicine,SeoulNationalUniversityCollegeofMedicine,
Seoul,Korea
Abstract
Background:Epidermalgrowthfactorreceptortyrosinekinaseinhibitor(EGFR-TKI)hasbeenshowntoexertasynergistic
antitumor effect when combined with
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