MicroRNA Fingerprints Identify miR-150 as a Plasma Prognostic Marker in Patients with Sepsis 英文参考文献.docVIP

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MicroRNA Fingerprints Identify miR-150 as a Plasma Prognostic Marker in Patients with Sepsis 英文参考文献.doc

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MicroRNA Fingerprints Identify miR-150 as a Plasma Prognostic Marker in Patients with Sepsis 英文参考文献

MicroRNAFingerprintsIdentifymiR-150asaPlasma PrognosticMarkerinPatientswithSepsis CatalinVasilescu1.,SimonaRossi2.,MasayoshiShimizu2,StefanTudor1,AngeloVeronese3 ,Manuela Ferracin3,MilenaS.Nicoloso2,ElisaBarbarotto2,MonicaPopa1,OanaStanciulea1,MichaelH. Fernandez4,DanTulbure5,CarlosE.Bueso-Ramos4,MassimoNegrini3,GeorgeA.Calin2* 1Department of Surgery, Fundeni Clinical Hospital, Bucharest, Romania, 2Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center,Houston,Texas,UnitedStatesofAmerica,3DepartmentofExperimentalandDiagnosticMedicine,InterdepartmentalCenterforCancerResearch,Universityof Ferrara,Ferrara,Italy,4DepartmentofHematopathology,TheUniversityofTexasM.D.AndersonCancerCenter,Houston,Texas,UnitedStatesofAmerica,5Department ofAnesthesiology,FundeniClinicalHospital,Bucharest,Romania Abstract Background: The physiopathology of sepsis continues to be poorly understood, and despite recent advances in its management,sepsisisstillalife-threateningconditionwithapooroutcome.Ifnewdiagnosticmarkersrelatedtosepsis pathogenesiswillbeidentified,newspecifictherapiesmightbedevelopedandmortalityreduced.Smallregulatorynon- codingRNAs,microRNAs(miRNAs),wererecentlylinkedtovariousdiseases;theaimofourprospectivestudywastoidentify miRNAs that can differentiate patients with early-stage sepsis from healthy controls and to determine if miRNA levels correlatewiththeseverityassessedbytheSequentialOrganFailureAssessment(SOFA)score. Methodology/PrincipalFindings:Byusinggenome-widemiRNAprofilingbymicroarrayinperipheralbloodleukocytes,we found that miR-150, miR-182, miR-342-5p, and miR-486 expression profiles differentiated sepsis patients from healthy controls. We also proved by quantitative reverse transcription-polymerase chain reaction that miR-150 levels were significantlyreducedinplasmasamplesofsepsispatientsandcorrelatedwiththelevelofdiseaseseveritymeasuredbythe SOFAscore,butwereindependentofthewhitebloodcounts(WBC).Wefoundthatplasmalevelsoftu