MicroRNA Patterns Associated with Clinical Prognostic Parameters and CNS Relapse Prediction in Pediatric Acute Leukemia 英文参考文献.docVIP

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MicroRNA Patterns Associated with Clinical Prognostic Parameters and CNS Relapse Prediction in Pediatric Acute Leukemia 英文参考文献.doc

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MicroRNA Patterns Associated with Clinical Prognostic Parameters and CNS Relapse Prediction in Pediatric Acute Leukemia 英文参考文献

MicroRNAPatternsAssociatedwithClinicalPrognostic ParametersandCNSRelapsePredictioninPediatric AcuteLeukemia HuaZhang1.,Xue-QunLuo2.,PengZhang4,5.,Li-BinHuang2,Yu-ShengZheng1,JunWu3,HuiZhou1, Liang-HuQu1,LingXu3*,Yue-QinChen1* 1KeyLaboratoryofGeneEngineeringoftheMinistryofEducation,StateKeyLaboratoryforBiocontrol,SunYat-senUniversity,Guangzhou,People’sRepublicofChina, 2TheFirstAffiliatedHospitalofSunYat-senUniversity,Guangzhou,People’sRepublicofChina,3TheSecondAffiliatedHospitalofSunYat-senUniversity,Guangzhou, People’sRepublicofChina,4InstituteofPathologyandSouthwestCancerCenter,SouthwestHospital,ThirdMilitaryMedicalUniversity,Chongqing,China,5Ooparts Corporation,Rockville,Maryland,UnitedStatesofAmerica Abstract Background:RecentreportshaveindicatedthatmicroRNAs(miRNAs)playacriticalroleinmalignancies,andregulationsin theprogressofadultleukemia.TheroleofmiRNAsinpediatricleukemiastillneedstobeestablished.Thepurposeofthis study wastoinvestigate theaberrantly expressedmiRNAsin pediatric acuteleukemia anddemonstrate miRNApatterns thatarepediatric-specificandprognosticparameter-associated. Methodology/Principal Findings: A total of 111 pediatric bone marrow samples, including 99 patients and 12 normal donors,wereenrolledinthisstudy.Ofthosesamples,36patientsand7normalsampleswereusedasatestcohortforthe evaluationofmiRNAprofiling;63pediatricpatientsand5normaldonorswereusedasavalidationcohorttoconfirmthe miRNAdifferentialexpression.PediatricALL-andAML-specificmicroRNAexpressionpatternswereidentifiedinthisstudy. The most highly expressed miRNAs in pediatric ALL were miR-34a, miR-128a, miR-128b, and miR-146a, while the highly expressed miRNAs in pediatric AML were miR-100, miR-125b, miR-335, miR-146a, and miR-99a, which are significantly differentfromthosereportedforadultCLLandAML.miR-125bandmiR-126mayserveasfavorableprognosticatorsforM3 andM2patients,respectively.Importantly,weidentifieda‘‘miRNAcascade’’associatedwithcentralnervoussystem(CNS) relapseinALL.Additionally,miRNA