Modeling the Impact of Lesions in the Human Brain 英文参考文献.docVIP

ModelingtheImpactofLesionsintheHumanBrain JeffreyAlstott1,MichaelBreakspear2,3,4,5,PatricHagmann6,7,LeilaCammoun6,7,OlafSporns1,8 * 1Program in Cognitive Science, Indiana University, Bloomington, Indiana, United States of America, 2Queensland Institute of Medical Research, Brisbane, Australia, 3Royal Brisbane and Women’s Hospital, Brisbane, Australia, 4School of Psychiatry, University of South Wales, Sydney, Australia, 5The Black Dog Institute, Sydney, Australia,6Signal Processing Laboratory 5, Ecole Polytechnique Fe′de′rale deLausanne, Lausanne, Switzerland, 7Department ofRadiology, University HospitalCenter, UniversityofLausanne,Lausanne,Switzerland,8DepartmentofPsychologicalandBrainSciences,IndianaUniversity,Bloomington,Indiana,UnitedStatesofAmerica Abstract Lesions of anatomical brain networks result in functional disturbances of brain systems and behavior which depend sensitively,oftenunpredictably,onthelesionsite.Theavailabilityofwhole-brainmapsofstructuralconnectionswithinthe humancerebrumandourincreasedunderstandingofthephysiologyandlarge-scaledynamicsofcorticalnetworksallowus toinvestigatethefunctionalconsequencesoffocalbrainlesionsinacomputationalmodel.Wesimulatethedynamiceffects oflesionsplacedindifferentregionsofthecerebralcortexbyrecordingchangesinthepatternofendogenous(‘‘resting- state’’) neural activity. We find that lesions produce specific patterns of altered functional connectivity among distant regionsofcortex,oftenaffectingbothcorticalhemispheres.Themagnitudeofthesedynamiceffectsdependsonthelesion locationandispartlypredictedbystructuralnetworkpropertiesofthelesionsite.Inthemodel,lesionsalongthecortical midline and in the vicinity of the temporo-parietal junction result in large and widely distributed changes in functional connectivity,whilelesionsofprimarysensoryormotorregionsremainmorelocalized.Themodelsuggeststhatdynamic lesioneffectscanbepredictedonthebasisofspecificnetworkmeasuresofstructuralbrainnetworksandthattheseeffects mayberelatedtok