Modeling the Worldwide Spread of Pandemic Influenza Baseline Case and Containment Interventions 英文参考文献.docVIP

Modeling the Worldwide Spread of Pandemic Influenza Baseline Case and Containment Interventions 英文参考文献.doc

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Modeling the Worldwide Spread of Pandemic Influenza Baseline Case and Containment Interventions 英文参考文献

o PL SMEDICINE ModelingtheWorldwideSpreadofPandemic Influenza:BaselineCaseandContainment Interventions Vittoria Colizza1,2,Alain Barrat2,3,Marc Barthelemy1,4,Alain-Jacques Valleron5,6,Alessandro Vespignani1,2* 1 School of Informatics and Center for Biocomplexity, Indiana University, Bloomington, Indiana, United States of America, 2 Complex Networks Lagrange Laboratory, InstituteforScientificInterchangeFoundation,Turin,Italy,3Unite′MixtedeRecherche8627,CentreNationaldelaRechercheScientifique,Universite′Paris-Sud,Orsay,France, 4Commissariata` l’EnergieAtomique,DirectionIle-de-France,Centred’EtudesdeBruye`resLeCha?tel, Bruye`resLeCha?tel, France,5Unite′ deRechercheenEpide′miologie, Syste`mes d’Information etMode′lisation, InstitutNationaldelaSante′ etdelaRechercheMe′dicale,Unite′ MixtedeRecherche707,Universite′ PierreetMarieCurie,Paris, France,6Ho?pitalSaint-Antoine,AssistancePublique-Ho?pitauxdeParis,Paris,France Funding:ABandAVarepartially fundedbytheEuropean ABSTRACT Commissioncontract001907 DynamicallyEvolvingLarge-scale InformationSystems(DELIS).AVis partiallyfundedbytheNational ScienceFoundationawardIIS- 0513650.Thefundershadnorolein studydesign,datacollectionand analysis,decisiontopublish,or preparationofthemanuscript. Background The highly pathogenic H5N1 avian influenza virus, which is now widespread in Southeast AsiaandwhichdiffusedrecentlyinsomeareasoftheBalkansregionandWesternEurope,has raisedapublicalerttowardthepotentialoccurrenceofanewsevereinfluenzapandemic.Here westudytheworldwidespreadofapandemicanditspossiblecontainmentatagloballevel takingintoaccountallavailableinformationonairtravel. CompetingInterests:Theauthors havedeclaredthatnocompeting interestsexist. MethodsandFindings AcademicEditor:AlisonP.Galvani, YaleUniversity,UnitedStatesof America We studied a metapopulation stochastic epidemic model on a global scale that considers airlinetravelflowdataamongurbanareas.Weprovidedatemporalandspatialevolutionofthe pandemicwithasensitivi

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