Modeling the Worldwide Spread of Pandemic Influenza Baseline Case and Containment Interventions 英文参考文献.docVIP
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Modeling the Worldwide Spread of Pandemic Influenza Baseline Case and Containment Interventions 英文参考文献
o
PL SMEDICINE
ModelingtheWorldwideSpreadofPandemic
Influenza:BaselineCaseandContainment
Interventions
Vittoria Colizza1,2,Alain Barrat2,3,Marc Barthelemy1,4,Alain-Jacques Valleron5,6,Alessandro Vespignani1,2*
1 School of Informatics and Center for Biocomplexity, Indiana University, Bloomington, Indiana, United States of America, 2 Complex Networks Lagrange Laboratory,
InstituteforScientificInterchangeFoundation,Turin,Italy,3Unite′MixtedeRecherche8627,CentreNationaldelaRechercheScientifique,Universite′Paris-Sud,Orsay,France,
4Commissariata` l’EnergieAtomique,DirectionIle-de-France,Centred’EtudesdeBruye`resLeCha?tel, Bruye`resLeCha?tel, France,5Unite′ deRechercheenEpide′miologie,
Syste`mes d’Information etMode′lisation, InstitutNationaldelaSante′ etdelaRechercheMe′dicale,Unite′ MixtedeRecherche707,Universite′ PierreetMarieCurie,Paris,
France,6Ho?pitalSaint-Antoine,AssistancePublique-Ho?pitauxdeParis,Paris,France
Funding:ABandAVarepartially
fundedbytheEuropean
ABSTRACT
Commissioncontract001907
DynamicallyEvolvingLarge-scale
InformationSystems(DELIS).AVis
partiallyfundedbytheNational
ScienceFoundationawardIIS-
0513650.Thefundershadnorolein
studydesign,datacollectionand
analysis,decisiontopublish,or
preparationofthemanuscript.
Background
The highly pathogenic H5N1 avian influenza virus, which is now widespread in Southeast
AsiaandwhichdiffusedrecentlyinsomeareasoftheBalkansregionandWesternEurope,has
raisedapublicalerttowardthepotentialoccurrenceofanewsevereinfluenzapandemic.Here
westudytheworldwidespreadofapandemicanditspossiblecontainmentatagloballevel
takingintoaccountallavailableinformationonairtravel.
CompetingInterests:Theauthors
havedeclaredthatnocompeting
interestsexist.
MethodsandFindings
AcademicEditor:AlisonP.Galvani,
YaleUniversity,UnitedStatesof
America
We studied a metapopulation stochastic epidemic model on a global scale that considers
airlinetravelflowdataamongurbanareas.Weprovidedatemporalandspatialevolutionofthe
pandemicwithasensitivi
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