Molecular Characterization of the Schistosoma mansoni Zinc Finger Protein SmZF1 as a Transcription Factor 英文参考文献.docVIP

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Molecular Characterization of the Schistosoma mansoni Zinc Finger Protein SmZF1 as a Transcription Factor 英文参考文献.doc

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Molecular Characterization of the Schistosoma mansoni Zinc Finger Protein SmZF1 as a Transcription Factor 英文参考文献

MolecularCharacterizationoftheSchistosomamansoni ZincFingerProteinSmZF1asaTranscriptionFactor MarcelaG.Drummond1.,CarlosE.Calzavara-Silva1,2.,DiegoS.D’Astolfo3,FernandaC.Cardoso4, MatheusA.Raja?o1,MarinaM.Moura?o1,ElisandraGava5,Se′rgioC.Oliveira4,Andre′aM.Macedo1, CarlosR.Machado1,Se′rgioD.J.Pena1,GregoryT.Kitten5,Glo′riaR.Franco1* 1Laborato′riodeGene′ticaBioqu?′mica,DepartamentodeBioqu?′micaeImunologia,InstitutodeCie?nciasBiolo′gicas,UniversidadeFederaldeMinasGerais,BeloHorizonte, Minas Gerais, Brazil, 2Laborato′rio de Imunologia Celular e Molecular, Centro de Pesquisas Rene′ Rachou, FIOCRUZ, Belo Horizonte, Minas Gerais, Brazil, 3Centro de Investigaciones en Bioqu?′mica Cl?′nica e Inmunolog?′a (CIBICI-CONICET), Departamento de Bioqu?′mica Cl?′nica, Facultad de Ciencias Qu?′micas, Universidad Nacional de Co′rdoba, Co′rdoba, Argentina, 4Laborato′rio de Imunologia de Doenc?as Infecciosas, Departamento de Bioqu?′mica e Imunologia, Instituto de Cie?ncias Biolo′gicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil, 5Laborato′rio do Desenvolvimento do Corac?a?o e Matriz Extracelular, Departamento de Morfologia,InstitutodeCie?nciasBiolo′gicas,UniversidadeFederaldeMinasGerais,BeloHorizonte,MinasGerais,Brazil Abstract Background: During its development, the parasite Schistosoma mansoni is exposed to different environments and undergoes many morphological and physiological transformations as a result of profound changes in gene expression. Characterization of proteins involved in the regulation of these processes is of importance for the understanding of schistosomebiology.Proteinscontainingzincfingermotifsusuallyparticipateinregulatoryprocessesandareconsidered the major class of transcription factors in eukaryotes. It has already been shown, by EMSA (Eletrophoretic Mobility Shift Assay), that SmZF1, a S. mansoni zinc finger (ZF) protein, specifically binds both DNA and RNA oligonucleotides. This suggeststhatthisproteinmightactasatranscriptionf